Richard S. Blumberg
Department of Medicine
Brigham and Women's Hospital
Medicine GI Division
75 Francis St., Thorn 1419
Boston, MA 02115
Lab Members: 8 Postdoctoral Fellows, 1 Instructor, 1 Assistant Professor
The laboratory studies mucosal immunity and focuses on several pathways that are especially relevant to the physiologic processes and diseases related to these compartments. As such, the laboratory has a particular interest in the manner in which aberrations of these physiologic processes lead to the development of inflammation, the management of the luminal microbial ecology, intestinal barrier dysfunction and cancer, among others.
The laboratory has four major areas of interest:
(1) Characterization of the neonatal MHC class I-related Fc receptor (FcRn) in epithelial cells and dendritic cells; (2) understanding carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) as a regulatory molecule on T and NK cells; (3) determining the role of the nonclassical MHC class I-related molecule, CD1d, and microsomal triglyceride transfer protein in mucosal immunity; and (4) evaluation of ER stress pathways in intestinal inflammation.
Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis ESS, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 2008;134:743-56.
Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, Glickman JN, Siebert R, Baron RM, Kasper DL, Blumberg RS. Microbial exposure during early life has persistent effects on natural killer T cell function. Science. 2012;336:489-93.
Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Rocken C, Arlt A, Gunther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang TJ, Blumberg RS. Hepatitis B Virus-Induced Alterations in Hepatocyte CDID Lipid Antigens Activate Natural Killer T Cells and Contribute to Protective Immunity. Nat Med. 2012;18:1060-8.
Chen L, Chen Z, Baker K, Halvorsen EM, Pires da Cunha A, Flak MB, Gerber G, Huang Y, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JWK, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS. Secretory immunity and pathogen resistance are mediated by CEACAM1-short isoforms in intestinal T cells. Immunity. 2012;37:930-46.
Tomczak M, Adolph T, Ko H-J, Bock J, Niederreiter L, Tschurtschenthaler M, Martinez-Naves E, Hartwig J, Hosomi S, Flak M, Cusick J, Billmann-Born S, Lucius R, Kweon M, Lee A-H, Hagen S, Glickman J, Choi A, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS. Endoplasmic reticulum stress converts epithelial autophagy defects into intestinal inflammation. Nature 2013; under revision.
For a complete listing of publications click here.
Last Update: 1/6/2014