Immunology
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Richard S. Blumberg

Department of Medicine
Brigham and Women's Hospital
75 Francis Street, Thorn 1419
Boston, MA 02115
Tel: 617-732-6917
Fax: 617-264-5185
email:rblumberg@partners.org
Webpage:Blumberg Lab Page
9 Postdoctoral Fellows, 1 Graduate Student

Richard Blumberg

The laboratory studies mucosal immunity and focuses on several molecules that the laboratory believes are operative and especially relevant to the physiologic processes and diseases related to these compartments. As such, the laboratory has a particular interest in the manner in which aberrations of these physiologic processes lead to the development of inflammatory bowel disease, the management of the luminal microbial ecology, intestinal barrier dysfunction and allergy, among others.

The laboratory has three major areas of interest:

  1. Characterization of the neonatal MHC class I-related Fc receptor (FcRn) in epithelial cells and dendritic cells;
  2. understanding carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) as a co-inhibitory molecule on T cells;
  3. determining the role of the nonclassical MHC class I-related molecule, CD1d, and microsomal triglyceride transfer protein in mucosal immunity.

 

Papers & Publications:

Yoshida M, Claypool SM, Mizoguchi E, Mizoguchi A, Roopenian DC, Lencer W, Blumberg, RS. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens into mucosal dendritic cells. Immunity 2004;20:769-83.

Bitonti AJ, Dumont JA, Low SC, Peters RT, Kropp K, Palombella VJ, Sattel JM, Lu Y, Tan CA, Song JJ, Garcia AM, Simister NE, Spiekermann GM, Lencer WI, Blumberg RS. Pulmonary delivery of a novel erythropoietin Fc-fusion protein in non-human primates using an immunoglobulin transport pathway. Proc Natl Acad Sci USA 2004;101:9763-8.

Zhu X, Peng J, Chen D, Liu X, Ye L, Iijima H, Kadaval K, Lencer WI, Blumberg RS. Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with b2-microglobulin in the endoplasmic reticulum. J Immunol 2005; 175:967-76.

Dougan SK, Salas A, Rava P, Agyemang A, Kaser A, Morrison J, Khurana A, Kronenberg M, Johnson C, Exley M, Hussain MM, Blumberg RS.  Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen presenting cells.  J Exp Med 2005;202:529-39.

Yoshida M, Kobayshi K, Kuo T, Bry L, Glickman J, Claypool SM, Kaser A, Nagaishi T, Higgins D, Mizoguchi E, Wakatsuki Y, Roopenian D, Mizoguchi A, Lencer, WI Blumberg RS.  Neonatal Fc receptor for IgG regulates mucosal immune response to luminal bacteria. J Clin Invest; In press.