K. Frank Austen
Astra Zeneca Professor of Respiratory and Inflammatory Diseases
Department of Medicine
Harvard Medical School and Brigham and Women's Hospital
Smith Building, Room 638
One Jimmy Fund Way
Boston MA 02115
The central focus of the laboratory continues to be on the molecular and cellular biology of the mast cell, the pathways of arachidonic acid metabolism to cysteinyl leukotrienes and prostanoids, and the cytokine regulation of the action of each of these components of allergic inflammation. As there is substantial evidence that innate signals are particularly prominent in allergic diseases, there is increasing attention to the adjuvants within the household allergens that accompany the immunogenic epitopes and on the priming or even circumvention of DC responses by innate effectors such as basophils, mast cells, eosinophils and epithelial cell derived cytokines.
Ago H, Kanaoka Y, Irikura D, Lam BK, Shimamura T, Austen KF, Miyano M. Crystal structure of a human membraine protein involved in cysteinyl leukotriene biosynthesis. Nature. 2007; 448:609-12.
Barrett NA, Maekawa A, Rahman OM, Austen KF, Kanaoka Y. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J Immunol. 2009; 182:1119-28.
Maekawa A, Balestrieri B, Austen KF, Kanaoka Y. GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. Proc Natl Acad Sci U S A. 2009;106:11685-90.
Austen KF, Maekawa A, Kanaoka Y, Boyce JA. The leukotriene E4 puzzle: Finding the missing pieces and revealing the pathobiologic implications. J Allergy Clin Immunol. 2009;124:406-14 Review.
Jones TG, Hallgren J, Humbles A, Burwell T, Finkelman FD, Alcaide P, Austen KF, Gurish MF. Antigen-induced increases in pulmonary mast cell progenitor numbers depend on interleukin-9 and CD1d-restricted NKT cells. J Immunol. 2009;183:5251-60.
Barrett NA, Austen KF. Innate cells and T helper 2 cell immunity in airway inflammation.Immunity. 2009;31:425-37. Review.
Immunology webpage updated 7/7//2010