Marc Vidal

Department of Genetics
Center for Cancer Systems Biology (CCSB) and

Department of Cancer Biology
Dana-Farber Cancer Institute Smith Bldg. Room 858
450 Brookline Ave.
Boston, MA 02115
Phone: 617-632-5114
Fax: 617-632-5739
Email: marc_vidal@dfci.harvard.edu
Web Page: The Vidal Lab Page
7 postdoctoral fellows, 3 graduate students (2 visiting)

Within cells macromolecules form complex intertwined networks of functionally interacting components. The molecular mechanisms underlying biological processes correspond to particular steady states adopted by such cellular networks. Systems-level theoretical conjectures about cellular networks have remained thin, largely because of lack of supporting experimental data.

To address how complex cellular networks relate to biology, we undertake, at the scale of the whole proteome, integrated approaches for mapping protein-protein interaction or “interactome” networks. The questions we face are: How are interactome networks organized at the scale of the whole cell? How can local and global features underlying this organization be uncovered? How are interactome networks disrupted in human disease, such as cancer?

References:

Zhong Q, Simonis N, Li QR, Charloteaux B, Heuze F, Klitgord N, Tam S, Yu H, Venkatesan K, Mou D, Swearingen V, Yildirim MA, Yan H, Dricot A, Szeto D, Lin C, Hao T, Fan C, Milstein S, Dupuy D, Brasseur R, Hill DE, Cusick ME, Vidal M. Edgetic perturbation models of human inherited disorders. Mol Syst Biol 2009; 3:321.
Dreze M, Charloteaux B, Milstein S, Vidalain PO, Yildirim MA, Zhong Q, Svrzikapa N, Romero V, Laloux G, Brasseur R, Vandenhaute J, Boxem M, Cusick ME, Hill DE, Vidal M. 'Edgetic' perturbation of a Caenorhabiditis elegans BCL-2 ortholog. Nat Methods 2009; 6:843-9.
Braun P, Tasan M, Dreze M, Barrios-Rodiles M, Lemmens I, H. Yu H, J.M. Sahalie JM, R.R. Murray RR, Roncari L, de Smet AS, Venkatesan K, Rual JF, Vandenhaute J, Cusick ME, Pawson T, Hill DE, Tavernier J, Wrana JL, Roth FP, Vidal M. An experimentally derived confidence score for binary protein-protein interactions. Nat Methods 2009; 6:91-97.
Venkatesan K, Rual JF, Vazquez A, Stelzl U, Lemmens I, Hirozane-Kishikawa T, Hao T, Zenkner M, Xin X, Goh KI, Yildirim MA, Simonis N, Heinzmann K, Gebreab F, Sahalie JM, Cevik S, Simon C, de Smet AS, Dann E, Smolyar A, Vinayagam A, Yu H, Szeto D, Borick H, Dricot A, Klitgord N, Murray RR, Lin C, Lalowski M, Timm J, Rau K, Boone C, Braun P, Cusick ME, Roth FP, Hill DE, Tavernier J, Wanker EE, Barabási AL, Vidal M. An empirical framework for binary interactome mapping. Nat Methods 2009;6:83-90.
Yu H, Braun P, Yildirim MA, Lemmens I, Venkatesan K, Sahalie J, Hirozane-Kishikawa T, Gebreab F, Li N, Simonis N, Hao T, Rual JF, Dricot A, Vazquez A, Murray RR, Simon C, Tardivo L, Tam S, Svrzikapa N, Fan C, de Smet AS, Motyl A, Hudson ME, Park J, Xin X, Cusick ME, Moore T, Boone C, Snyder M, Roth FP, Barabási AL, Tavernier J, Hill DE, Vidal M. High quality binary protein interaction map of the yeast interactome network. Science 2008; 322:104-10.

BBS webpage updated 6/14/2010