David A. Sinclair
Department of Genetics
New Research Building, Room 0931B
77 Avenue Louis Pasteur
Boston, MA 02115
Lab Members: 4 postdoctoral fellows, 4 graduate students, 1 undergraduate student, 1 lab manager
Visit my lab page here.
Why do we grow old? Why does aging cause disease? Can we slow aging or even reverse it? These are some of the greatest unsolved questions in biology. Advances in technology are allowing us to probe these questions more deeply and more rapidly than ever. By tackling these questions, we aim to develop medicines that may one day prevent and/or treat multiple common diseases at once. Our ultimate goal is to allow people to live healthier, disease-free lives. We focus on genes (e.g. sirtuins) and small molecules (e.g. resveratrol) that mimic exercise and calorie restriction, a diet that slows the pace of aging in animals. We use mouse models to test genes and small molecules for their ability to protect against common age-related diseases such as cancer, heart disease, Alzheimer’s disease, cardiovascular disease, infertility, and type II diabetes. At the cellular level we study epigenetics, cellular metabolism and mitochondrial function, neuroprotection, and cellular senescence. Expertise in the lab ranges from enzymology and biochemistry, to genetics and systems biology, to mouse models and pharmacology. Graduate students in the lab develop a comprehensive set of skills and knowledge about a variety of diseases and their underlying cellular processes, preparing them for a career in academia and/or drug discovery.
Price, N.L., Gomes, A.P., Ling, A.J., Martin-Montalvo, A, North, B.J., Hubbard, B.P., Agarwal,B. Davis,J., Varamini, B. Hafner, A., Rolo,A., Palmeira,C.M., de Cabo,R., Baur,J., and Sinclair, D.A. (2012) SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metabolism, 15(5): 675-90
Sinclair, D.A. and Tilly, J. (2013) Germline energetics, aging and female infertility. Cell Metabolism, in press
Hubbard, P., Gomes, A., Li, J., Dai, H., Stevens, L., Pentalout, B., Lamming, D., Moss, J., Howitz, K., Hamaro, Y., Vlasuk, G. and Sinclair, D.A. (2013). Evidence for a common mechanism of Sirt1 activation by small molecules. Science, in press
Biason-Lauber, A., Böni-Schnetzler,. M., Hubbard, B.P., et al., Glaser, B., Sinclair, D.A., and Donath, M.Y. Mutation of SIRT1 in Familial Type 1 Diabetes. Cell Metabolism, in press
Armour, S.M., Bennett, E.J., Zhang, X-Y, McMahon, S.B., Harper, J.W., Sinclair, D.A. Interaction of the deubiquitinase USP22 with SIRT1 regulates the SAGA coactivator complex. Mol. Cell Biol., in press
For a complete listing of publications click here.
Last Update: 2/12/2013