Jen Sheen

Department of Genetics
Harvard Medical School
Department of Molecular Biology
Massachusetts General Hospital
Simches 7624E, CRPN
185 Cambridge St.
Boston, MA 02114
Tel: (617) 726-5916
Fax: (617) 726-6893
Email: sheen@molbio.mgh.harvard.edu
Web Page: The Sheen Lab Page
15 postdoctoral fellows

Our laboratory studies the cellular and molecular mechanisms underlying plant responses to central growth and developmental regulators, such as glucose, energy, hormones and stresses, as well as pathogenic suppressors and microbial elicitors of host immunity. We are especially interested in developing simple and powerful assays to systematically explore plant genome resources and uncover novel plant gene functions. We have used an integrated approach, by combining genomic, cellular, biochemical, genetic, proteomic and bioinformatic tools, to discover key regulatory genes and molecules that control diverse plant signal transduction pathways. Our recent studies are unraveling the molecular and biochemical nature of receptors/sensors and signaling cascades and regulatory circuitry that mediate responses to glucose, energy, stress, cytokinin, auxin, abscisic acid, ethylene, and microbe-associated molecular patterns in plant innate immunity. We are currently interested in integrating signaling networks in whole plants from embryogenesis to senescence.

Sheen Lab website:

http://genetics.mgh.harvard.edu/sheenweb/index.html
http://ccib.mgh.harvard.edu/sheenlab-research.htm

References:

• Yoo, S.D., Cho, Y.H., Tena, G., Xiong, Y., and Sheen, J. 2008. Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling. Nature 451: 789-795.
• Baena-González, E., Rolland, F., Thevelein, J., and Sheen, J. 2007. A central integrator of transcription networks in plant stress and energy signalling. Nature 448: 938-942.
• He, P., Shan, L., Lin, N.-C., Martin, G.B. Kemmerling, B., Nurnberger, T., and Sheen, J. 2006. Specific bacterial suppressors of MAMP signaling upstream of MAPKKK in Arabidopsis innate immunity. Cell 125: 563-575.
• Cho, Y.H., Yoo, S.D., and Sheen, J. 2006. Regulatory functions of nuclear hexokinase1 complex in glucose signaling. Cell 127: 579-589.