Jen Sheen

Department of Genetics
Harvard Medical School
Department of Molecular Biology
Massachusetts General Hospital
Simches 7624E, CRPN
185 Cambridge St.
Boston, MA 02114
Tel: (617) 726-5916
Fax: (617) 726-6893
Email: sheen@molbio.mgh.harvard.edu
Web Page: The Sheen Lab Page
16 postdoctoral fellows

Our laboratory investigates the cellular and molecular mechanisms underlying plant responses to central regulators, such as sugars, hormones, stresses, and pathogen elicitors. We are especially interested in developing simple and powerful assays to efficiently explore plant genome resources. We have used an integrated approach, by combining genomic, cellular, biochemical, genetic, proteomic and bioinformatic tools, to discover key regulatory genes and molecules that control diverse plant signal transduction pathways. Our recent studies have uncovered the molecular and biochemical nature of receptors/sensors and signaling cascades that mediate responses to glucose, cytokinin, auxin, abscisic acid, ethylene, H2O2, and microbe associated molecular patterns (MAMPs) in plant innate immunity. We are also interested in integrating signaling networks in whole plants from embryogenesis to senescence.

Sheen Lab website:

http://genetics.mgh.harvard.edu/sheenweb/index.html

References:

• Baena-González, E., Rolland, F., Thevelein, J.M., and Sheen, J. 2007. A central integrator of transcription networks in plant stress and energy signalling. Nature. in press
• He, P., Shan, L., Lin, N. C., Martin, G. B., Kemmerling, B., Nurnberger, T., and Sheen, J. 2006. Specific bacterial suppressors of MAMP signaling upstream of MAPKKK in Arabidopsis innate immunity. Cell, 125: 563-575
• Cho, Y.H., Yoo, S.D., and Sheen, J. 2006. Regulatory functions of nuclear hexokinase1 complex in glucose signaling. Cell, 127: 579-589
• Rolland, F., Baena-González, E., and Sheen, J. 2006. Sugar sensing and signaling in plants. Ann. Rev. Plant Biol. 57: 675-709.