Frederick (Fritz) Roth

Department of Biological Chemistry and Molecular Pharmacology
Harvard Medical School
Seeley G. Mudd Building, Room 322
250 Longwood Ave
Boston, MA 02115
Tel: (617) 432-3551
Fax: (617) 432-3557
Email: fritz_roth@hms.harvard.edu
Web page: The Roth Lab Page

9 postdoctoral fellows, 1 graduate student

Current experimental interests:

• Using parallel sequencing to phenotype all pairwise deletion combinations of genes in S. cerevisiae, with initial application to study of transcription elongation.
• Generation of S. cerevisiae strains carrying dozens of precisely engineered loci, with initial application to delete all ABC transporters imparting multidrug resistance.

Current computational interests:

• Systematic analysis of genetic interacton to reveal redundant systems and order of action in genetic pathways.
• Integrating large-scale studies to quantitatively assign function to genes and guide experimentation and disease association studies.

References:

• JD Klekota & FP Roth†. Chemical substructures that predict biological activity: Exposing the rules of privilege. Bioinformatics 24(21):2518-2525 (2008).
• RP St.Onge, R Mani, J Oh, M Proctor,E Fung, R Davis, C Nislow, FP Roth† & G Giaever†. Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions. Nature Genetics. 39(2):199-206 (2007).
• L Peña-Castillo, M Tasan, CL Myers, H Lee, T Joshi, C Zhang, Y Guan, M Leone, A Pagnani, WK Kim, C Krumpelman, W Tian, G Obozinski, Y Qi, S Mostafavi, GN Lin, GF Berriz, FD Gibbons, G Lanckriet, J Qiu, C Grant, Z Barutcuoglu, DP Hill, D Warde-Farley, C Grouios, D Ray, JA Blake, M Deng, M Jordan, WS Noble, Q Morris, J Klein-Seetharaman, Z Bar-Joseph, T Chen, F Sun, OG Troyanskaya, EM Marcotte, D Xu, TR Hughes† & FP Roth†. A critical assessment of M. musculus gene function prediction using integrated genomic evidence. Genome Biology (2008).
• R Mani, RP St. Onge, J Hartman, G Giaever, FP Roth†. Defining genetic interaction. Proceedings of the National Academy of Sciences 105(9):3461-3466 (2008).