William Pu

Department of Cardiology
Children's Hospital Boston
300 Longwood Avenue
Boston, MA 02115
Tel: (617) 919-2091
Fax: (617) 730-0140
Email: wpu@enders.tch.harvard.edu
9 postdoctoral fellows, 2 technicians

Web Page : The Pu Lab

The laboratory is interested in the regulation of gene expression in heart development and heart failure. We seek to apply our understanding of heart development towards regenerative approaches to congenital and acquired heart disease.

Current Projects:

1. Transcriptional regulation of heart development and heart function.
2. microRNA regulation of gene expression in the heart
3. Epicardial contributions to the developing and adult heart
4. Modeling heart disease with iPS technology

References:

Zhou, B., Ma, Q., Kong, S.W., Hu, Y., Campbell, P.H., McGowan, F.X., Ackerman, K.G., Wu, B., Zhou, B., Tevosian, S.G., and Pu, W.T. 2009. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest. 119:1462-1476.
Zhou, B., Ma, Q., Rajagopal, S., Wu, S.M., Domian, I., Rivera-Feliciano, J., Jiang, D., von Gise, A., Ikeda, S., Chien, K.R., and Pu, W.T. 2008. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 454:109-113.
Rivera-Feliciano, J., Lee, K.H., Kong, S.W., Rajagopal, S., Ma, Q., Springer, Z., Izumo, S., Tabin, C.J., and Pu, W.T. 2006. Development of heart valves requires Gata4 expression in endothelial-derived cells. Development. 133:3607-3618.
Bisping, E., Ikeda, S., Kong, S.W., Tarnavski, O., Bodyak, N., McMullen, J.R., Rajagopal, S., Son, J.K., Ma, Q., Springer, Z., Kang, P.M., Izumo, S., and Pu, W.T. 2006. Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure. Proc Natl Acad Sci U S A. 103:14471-14476.

BBS webpage updated 12/02/2009