Pier Paolo Pandolfi, M.D., Ph.D.
Department of Pathology
CLS Building, Room 401
330 Brookline Ave.
Boston, MA 02215
Tel: 617-735-2161
Fax: 617-735-2120
Email: ppandolf@bidmc.harvard.edu
My laboratory is dedicated to understanding the mechanisms that lead to tumorigenesis. We have developed unique mouse models and tools that allow us not only to study genetic alterations associated with the disease but that can also be used for the pre-clinical assessment of new therapeutic approaches aimed at the eradication of cancer. In turn, this will have an important impact on human health, as results will be utilized to facilitate the identification of patient subtypes through key genetic determinants and biomarkers that predict response to specific treatments.
References:
H.-K. Lin, S. Bergmann and P.P. Pandolfi. Cytoplasmic PML function in TGF-b signaling. Nature, 431:205-11, 2004.
S. Grisendi, R. Bernardi, M. Rossi, K. Cheng, L. Khandker, K. Manova and P.P. Pandolfi. Role of Npm in embryonic development and tumourigenesis. Nature, 437:147-53, 2005.
T. Maeda, R. Hobbs, T. Merghoub, I. Guernah, A. Zelent, C. Cordon-Cardo, J. Teruya-Feldstein and P.P. Pandolfi. Role of the proto-oncogene POKEMON in cellular transformation and ARF repression. Nature, 433:278-285, 2005.
L.C. Trotman, A. Alimonti, P.P. Scaglioni, J.A. Koutcher, C. Cordon-Cardo and P.P. Pandolfi. Identification of a tumour suppressor network opposing nuclear Akt function. Nature, 441:523-7 2006.
P.P. Scaglioni, T. Yung, L-F Cai, H. Erdjument-Bromage, B. Singh, J. Teruya-Feldstein, P. Tempst and P.P. Pandolfi. A novel CK2-dependent pathway for PML degradation upon cellular and oncogenic stress. Cell, 126:269-283, 2006.
R. Bernardi, I. Guernah, D. Jin, C. Cordon-Cardo, M. Celeste Simon, S. Rafii and P.P. Pandolfi. PML inhibits Hif-1a translation and neoangiogenesis through repression of mTOR. Nature, 442:779-785, 2006.
K. Ito, R. Bernardi, A. Morotti, S. Matsuoka, G. Saglio, Y. Ikeda, J. Rosenblatt. D.E. Avigan, J. Teruya-Feldstein and P.P. Pandolfi. PML targeting eradicates quiescent leukemia initiating cells. Nature, 453(7198):1072-8, 2008. Epub 2008 May 11.
M.S. Song, L. Salmena, A. Carracedo-Perez, A. Egia, F. Lo Coco, J. Teruya-Feldstein and P.P. Pandolfi. The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. Nature, 455(7214):813-7, 2008. Epub 2008 August 20.
H. K. Lin, Z. Chen, G. Wang, C. Nardella, K.I. Nakayama, C. Cordon-Cardo, J. Teruya-Feldstein, S.W. Lee, C. H. Chan, W.L. Yang, J. Wang, A. Egia and P.P. Pandolfi. Skp2 targeting suppresses tumorigenesis in vivo through induction of cellular senescence independently of p19Arf/p53. Nature, 2010 Mar 18;464(7287):374-9.
L. Poliseno, L. Salmena, J. Zhang, B. Carver, W. J. Haveman , P.P. Pandolfi. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature. 2010 Jun 24;465(7301):1033-8. PubMed PMID: 20577206.
R.M. Hobbs, M. Seandel, I. Falciatori, S. Rafii, P.P. Pandolfi. Plzf Regulates Germline Progenitor Self-Renewal by Opposing mTORC1. Cell. 2010 Aug 6;142(3):468-479. PubMed PMID: 20691905.