BBS Faculty Member - Richard Mitchell

Richard Mitchell

Department of Pathology and Health Sciences and Technology

Harvard Medical School
Brigham and Women's Hospital
77 Avenue Louis Pasteur, NRB 730D
Boston MA 02115
Tel: 617-525-4303
Fax: 617-525-4329
Email: rmitchell@rics.bwh.harvard.edu
Lab Members: 1 postdoctoral fellow



The laboratory focuses on understanding the mechanisms of acute and chronic rejection in solid-organ allografts, and more broadly examining the interactions of inflammatory cells with vessel walls. These processes have direct relevance not only to transplantation, but also to in-stent restenosis, vein graft intimal hyperplasia, and atherosclerosis. In vivo murine aortic and cardiac allografts constitute a significant portion of the research, with patterned co-cultures and nanotechnology being increasingly used to model the interactions of innate and adaptive immune elements with endothelial or smooth muscle cells. Monoclonal antibody blockade and/or targeted deletions or knock-downs of various cytokines, chemokines, or their receptors permit examination of the roles of selected mediators and costimulatory molecules. Potential therapeutic strategies are also being formally tested in the various models. This work has shown the critical role of interferon-g in driving allograft arteriopathy and of interleukin-4 in inducing aneurysms. We have also demonstrated the contribution of circulating bone marrow-derived precursor cells to the process of vascular intimal hyperplasia.



Last Update: 5/29/2014



Publications

For a complete listing of publications click here.

 


 

Shimizu K, Sugiyama S, Aikawa M, Fukumoto Y, Rabkin E, Libby P, Mitchell RN. Host bone marrow cells are a source of donor intimal smooth muscle-like cells in murine aortic transplant arteriopathy. Nature Med. 2001; 7:738-741

Shimizu K, Aikawa M, Takayama K, Libby P, Mitchell RN. Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statins. Circulation 2003; 108:2113-2120

Shimizu K, Shichiri M, Libby P, Lee RT, Mitchell RN. Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas. J Clin Invest. 2004;114:300-8

Mitchell RN. Graft Vascular Disease: Immune Response Meets the Vessel Wall. Annu Rev Pathol. 2009; 4:19-47.

Shimizu K, Libby P, Rocha VC, Folco EJ, Shubiki R, Grabie N, Jang S, Lichtman AH, Shimizu A, Hogg N, Simon DI, Croce K, Mitchell RN.
Loss of myeloid related protein-8/14 exacerbates cardiac allograft rejection. Circulation 2011; 124:2920-3292



© 2013 by the President and Fellows of Harvard College