Jordan Kreidberg
Department of Pediatrics
Children's Hospital
Enders Building, Room 878
300 Longwood Ave.
Boston, MA 02115
Tel: (617) 919-2959
Fax: (617) 730-0129
Email: Jordan.kreidberg@childrens.harvard.edu
12 postdoctoral fellows
Our research focuses on how stem cell and progenitor populations in developing organs are regulated by signaling networks. Important areas of study include how transcription factors and chromatin modification proteins are involved in organ development. We have taken a genome-wide approach to identifying targets of the Wilms’ tumor-1 transcription factor (WT1) using chromatin immunoprecipitation, using chromatin from embryonic kidneys. These studies have provided evidence that WT1 regulates chromatin modification in development, and future studies will examine histone modifications in development and disease models that are regulated by WT1.
We are also studying the role of microRNAs in kidney progenitor cells, and we have begun to identify microRNAs required to maintain progenitor populations and molecular pathways regulated by microRNAs.
Our studies on organ development are being extended to several disease models. Polycystic Kidney Disease (PKD) is one of the most common genetic diseases. We are investigating roles for integrins and receptor tyrosine kinases in the pathogenesis of PKD. These studies have identified a role for Wnt signaling in PKD that we are continuing to investigate. We are also using high throughput sequencing to characterize changes in global microRNA expression in PKD, that will elucidate new roles for microRNAs in human disease.
References:
- Liu Y, Chattopadhyay N, Qin S, Szekeres C, Vasylyeva T, Mahoney ZX, Taglienti M, Bates CM, Chapman HA, Miner JH, Kreidberg JA. Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis. Development. 2009 136: 843-853
- Ho J, Ng KH, Rosen S, Dostal A, Gregory RI, Kreidberg JA. Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrology. 2008 Nov;19(11):2069-75
- Kazama, I., Mahoney, Z., Miner, J.H., Graf, D., Economides, A.N., Kreidberg, J.A. Podocyte-derived BMP7 is critical for nephron development.. J. Amer. Soc. of Nephrology. 2008 Nov;19(11):2181-91
BBS webpage updated 12/02/2009