Victor W. Hsu
Department of Medicine
Brigham and Women's Hospital
One Jimmy Fund Way, Smith 538B
Boston, MA 02115
Tel: (617) 525-1103
Fax: (617) 525-1104
Email: vhsu@rics.bwh.harvard.edu
3 postdoctoral fellows and 2 instructors
We are interested in understanding mechanisms of vesicular transport and are also applying these insights to elucidating physiology and disease mechanisms. Coat proteins initiate, and thereby define, intracellular transport pathways. We have identified a novel coat complex for endocytic recycling, a pathway critical for many cellular events. At a more fundamental level, we have found that coat complexes cooperate with critical lipids to “bend” the membrane bilayer in achieving vesicle formation. Our insights have also led us to elucidate molecular mechanisms that underlie cell migration, metabolic homeostasis, and viral pathogenesis.
References:
- Li, J, Peters, PJ, Bai, M., Dai, J., Bos, E., Kirchhausen, T., Kandror, KV, Hsu, VW. An ACAP1-containing clathrin coat complex for endocytic recycling. Journal of Cell Biology 2007; 178: 453-464.
- Yang, J.S., Gad, H., Lee, S.Y., Mironov, A., Zhang, L., Beznoussenko, G.V., Valente, C., Turacchio, G., Bonsra, A.N., Du, G., Baldanzi, G, Graziani, A, Bourgoin, S, Frohman, MA, Luini, A, Hsu, VW. A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance. Nature Cell Biology 2008; 10: 1146-1153.
- Zhang, L., Lee, S.Y., Beznoussenko, G.V., Peters, P.J., Yang, J.S., Gilbert, H.Y., Brass, A.L., Elledge, S.J., Isaacs, S.N., Moss, B., Mironov, A., Hsu, V.W. A role for the host coatomer and KDEL receptor in early vaccinia biogenesis. Proceedings of the National Academy of Sciences, USA 2009; 106: 163-168.
- Hsu, V.W., Lee, S.Y., and Yang, J.S. The evolving understanding of COPI vesicle formation. Nature Reviews Molecular Cell Biology 2009; 10: 360-364.
BBS webpage updated 12/02/2009