David E. Clapham

Department of Neurobiology
Children's Hospital
Enders Building, Rm 1309
320 Longwood Avenue
Boston, MA 02115
Tel: (617) 919-2680
Fax: (617) 731-0787
Email: dclapham@enders.tch.harvard.edu
Web Page: The Clapham Lab Page

We study signal transduction, primarily the control of ion channels in heart and brain. We study the molecules that control the entry and release of intracellular calcium, and the mechanisms of calcium control of cell function. For a detailed description of our work, including figures, movies, and references, see the web at http://clapham.tch.harvard.edu and and http://www.hhmi.org/.

References:

• Clapham, DE. Calcium Signaling. Cell, 2007, 131:1047-1058.
• Ramsey, IS, Moran, MM, Chong, JA, and Clapham, DE. A voltage-gated proton-selective channel lacking the pore domain. Nature, 2006, 440, 7088:1213-1216.
• Kirichok, Y, Navarro, B, and Clapham, DE. Whole-cell patch clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature 2006, 439 (7077), 737-740.
• Clapham, DE. Mammalian TRP Channels, Cell, 2007, 129, 1:220.
• Jin, J, Desai, BN, Navarro, B, Donovan, A, Andrews, NC, and Clapham, DE. Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science, 2008, 322, 756-760. DOI: 10.1126/ science. 1163493. PMCID: PMC2605283.
• Riccio, A, Li, Y, Moon, J, Kim, K-S, Smith, KS, Rudolph, U, Gapon, S, Yao, GL, Tsvetkov, E, Rodig, SJ, Van't Veer, A, Meloni, EG, Carlezon Jr, WA, Bolshakov, VY, and Clapham, DE. Essential role for TRPC5 in amygdala function and fear-related behavior. 2009; Cell, 137, May 15, 761-772. doi:10.1016/j.cell.2009.03.039.