Biological and Biomedical Science
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George M. Church

Department of Genetics
Harvard Medical School
New Research Building, Room 238
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: (617) 432-7562
Fax: (617) 432-7266
Email:http://arep.med.harvard.edu/gmc/email.html
Web Page: The Church Lab Page
18 postdoctoral fellows, 14 graduate students

Our research focuses on new genomic & proteomic measurement and modeling methods for biomedical & ecological systems. In particular, we focus on cell-cycle, metabolic regulation, epigenetics and recombination in stem cells and microbial ecosystems (ocean circadian cycles & biofilms). We continue developing genome engineering and synthetic biology to test computational hypotheses flowing from the above systems as well as build genetic circuits (e.g. intracellular counters), vaccines, and optimal drug biosyntheses. We have developed new sequencing methods both to help analyze the output of combinatorial selections as well as test-run a full genotype-phenotype database to pave the way to affordable personal genomics. We can sequence multiple sites (i.e. haplotype) single human chromosome molecules (up to 150 Mbp long) and determine alternative splicing on single RNA molecules (e.g. CD44 spliceforms in cancer).

 

References:

  • Tian J, Gong H, Sheng N, Zhou X, Gulari E, Gao X, & Church GM (2004) Accurate Multiplex Gene Synthesis from Programmable DNA Chips. Nature 432: 1050-4
  • Zhu,J, Shendure,J, Mitra, RD, Church, GM (2003) Single Molecule Profiling of Alternative Pre-mRNA Splicing. Science. 2003 Aug 8;301(5634):836-8.
  • Shendure J, Mitra R, Varma C, Church GM (2004) Advanced Sequencing Technologies: Methods and Goals. Nature Reviews of Genetics May;5(5):335-44