George M. Church

Department of Genetics
Harvard Medical School
New Research Building, Room 238
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: (617) 432-7562
Fax: (617) 432-7266
Email: http://arep.med.harvard.edu/gmc
Web Page: The Church Lab Page
18 postdoctoral fellows, 14 graduate students

Our research focuses on new technologies for genomic & proteomic measurement, synthesis and modeling of biomedical & ecological systems -- in particular, personal genomics and biofuels. We have developed next-generation sequencing methods to analyze the output of combinatorial selections as well as comprehensive gene-environment-trait data for affordable personalized medicine. We reprogram human skin-derived pluripotent skin cells to connect cis-regulatory motif variants in populations to allele-specific and cell-type-specific RNA measures and further to causal effects on cell and larger-scale morphologies. We are developing tools for connecting functional microbiomics with (VDJ-ome) immune responses.

References:

• Li JB, Levanon EY, Yoon J-K, Aach J, Xie B, LeProust E, Zhang K, Gao Y, Church GM (2009) Genome-wide Identification of Human RNA Editing Sites by Massively Parallel DNA Capturing and Sequencing. Science. 2009 May 29;324(5931):1210-3.

• Wang HH, Isaacs FJ, Forest CR, Sun ZZ, Xu G, Church GM (2009) Multiplexed Genome Engineering and Directed Evolution. Nature in press

• Ball MP, Li JB, Gao Y, Lee JH, LeProust EM, Park IH, Xie B, Daley GQ, Church GM. Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol. 2009 Apr;27(4):361-8.

• Dantas G, Sommer MO, Oluwasegun RD, Church GM. Bacteria subsisting on antibiotics. Science. 2008 Apr 4;320(5872):100-3.