Lewis Cantley
Department of Systems Biology
Beth Israel Hospital
Center of Life Sciences Building, Room 412
3 Blackfan Circle
Boston, MA 02115
Tel: (617) 735-2601
Fax: (617) 735-2646
Email: lcantley@hms.harvard.edu
13 postdoctoral fellows, 3 graduate students
The major research objective of our laboratory is to understand the biochemical and genetic basis for cell growth regulation by growth factors and hormones. Research from our laboratory has led to the elucidation of a pathway by which growth factors stimulate nutrient uptake and cellular metabolism, leading to increased cell growth and cell survival. Defects in homeostatic control of this signaling network can lead to cancers or to diabetes or metabolic disease. A central node in this network is the enzyme phosphoinositide 3-kinase. In order to explore the in vivo role of this network we are generating mice in which components of the network can be switched on or off to determine their effects on cancers and other diseases
References: For a complete listing of publications on PubMed, click here.
BBS webpage updated 12/03/2009