BBS Faculty Member - Marianne Wessling-Resnick

Marianne Wessling-Resnick

Department of Genetics and Complex Diseases

Harvard School of Public Health
Dept. of Genetics and Complex Diseases, SPH2-123
665 Huntington Avenue
Boston, MA 02115
Tel: 617-432-3267
Fax: 617-432-5236
Email: wessling@hsph.harvard.edu
Lab Members: 5 postdoctoral fellows, 1 graduate student



Dr. Wessling-Resnick’s current research effort focuses on genetic disorders of iron metabolism at the molecular level and their implications in complex disease. She has an on-going program to establish new pharmacological tools through small molecule screening in order to identify molecular elements of iron transport. These efforts led to discovery of ferristatin, an inhibitor of transferrin-mediated iron uptake that acts by degrading the transferrin receptor. Her studies also focus on the role of iron status (deficiency and overload) in the absorption of inhaled metals. These efforts have established the pharmacokinetics of pulmonary manganese and iron uptake from the lungs to the blood and defined the influence of high iron diet as well as the effects of iron deficiency due to diet and phlebotomy. A major finding has been that anemia promotes manganese absorption across the olfactory tract into the brain, and using genetic models, her work has defined the mechanistic role of Divalent Metal Transporter-1. Her on-going investigations are support by two R01 grants from NIDDK and NIEHS.



Last Update: 8/22/2013



Publications

For a complete listing of publications click here.

 


 



© 2013 by the President and Fellows of Harvard College