BBS Faculty Member - Marc Vidal

Marc Vidal

Department of Genetics

Dana Farber Cancer Institute
Smith Bldg., Rm. 858A
450 Brookline Ave.
Boston, MA 02215
Tel: 617-632-5114
Fax: 617-632-5739
Lab Members: 10 postdoctoral fellows, 2 graduate students
Visit my lab page here.

Within cells macromolecules form complex intertwined networks of functionally interacting components. The molecular mechanisms underlying biological processes correspond to particular steady states adopted by such cellular networks. Systems-level theoretical conjectures about cellular networks have remained thin, largely because of lack of supporting experimental data.

To address how complex cellular networks relate to biology, we undertake, at the scale of the whole proteome, integrated approaches for mapping protein-protein interaction or “interactome” networks. The questions we face are: How are interactome networks organized at the scale of the whole cell? How can local and global features underlying this organization be uncovered? How are interactome networks disrupted in human disease, such as cancer?

Last Update: 8/7/2015


For a complete listing of publications click here.



Rozenblatt-Rosen O, Deo RC, Padi M, Adelmant G, Calderwood MA, Rolland T, Grace M, Dricot A, Askenazi M, Tavares, M, Pevzner S, Abderazzaq F, Byrdsong D, Carvunis, AR, Chen A, Cheng J, Correll M, Duarte M, Fan C, Feltcamp, FC, Ficaro SB, Franchi R, Garg B, Gulbahce N, Hao, T, Holthaus AM, James R, Korkhin A, Litovchick L, Mar JC, Rabello S, Rubio R, Shen Y, Singh S, Spangle JM, Tasan M, Wanamaker S, Webber JT, Roecklein-Canfield J, Johannsen E, Barabási AL, Beroukhim R, Kieff E, Cusick ME, Hill DE, Münger K, Marto JA*, Quackenbush J*, Roth FP*, DeCaprio JA*, Vidal M*. Interpreting cancer genomes using systematic host perturbations by tumour virus proteins. Nature 2012; 487:491-5 (* = co-corresponding authors).

Carvunis AR, Rolland T, Wapinski I, Calderwood MA, Yildirim MA, Simonis N, Charloteaux B, Hidalgo CA, Barbette J, Santhanam B, Brar GA, Weissman JS, Regev A, Thierry-Mieg N, Cusick ME, Vidal M. Protogenes and
de novo gene birth. Nature 2012; 487:370-74.

Yang X, Boehm JS, Yang X, Salehi-Ashtiani K, Hao T, Shen Y, Lubonja R, Thomas S, Alkan O, Bhimdi T, Green TM, Johannessen CM, Silver S, Nguyen C, Murray RR, Hieronymus H, Balcha D, Fan C, Lin C, Ghamsari L, Vidal M*, Hahn WC*, Hill DE*, Root DE*. A public genome-scale lentiviral expression library of validated human ORFs.
Nat Methods 2011; 8:659-61. (* = co-corresponding authors).

Arabidopsis Interactome Mapping Consortium*. Evidence for network evolution in an Arabidopsis interactome map. Science 2011; 333:601-7. (* = Vidal M, JR Ecker, Braun P, Hill DE co-corresponding authors).

Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T*, Vidal M*, Iakoucheva LM*. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Nat Commun 2014;5:3650. (* = co-corresponding authors).

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