BBS Faculty Member - David Scadden

David Scadden

Co-Chair, Department of Stem Cell and Regenerative Biology
Co-Director, Harvard Stem Cell Institute
Director, MGH Center for Regenerative Medicine

Massachusetts General Hospital
Director, MGH Center for Regenerative Medicine
185 Cambridge St., CPZN #4265A
Boston, MA 02114
Tel: 617-726-5615
Fax: 617-724-2662

Harvard University
Sherman Fairchild 258B
7 Divinity Ave.
Cambridge, MA 02138
Tel: 617-496-7478
Fax: 617-496-8324
Lab Members: 15 postdoctoral fellows, 2 graduate students, 6 undergraduate students
Visit my lab page here.

The Scadden laboratory focuses on stem cell interactions with their niche. Stem cell function is governed by input from local and systemic environments that determine how the stem cell pool contributes to the basic physiologic processes of tissue growth, maintenance and repair. Disturbance of the interaction between stem and niche cells can change the persistence of stem cells or distort their ordered differentiation and result in neoplasia. We study the hematopoietic system in mouse and man to define the nature of the stem cell – niche relationship and how it may be manipulated to alter the outcome of hematologic disease.

Last Update: 7/30/2015


For a complete listing of publications click here.



Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmanker JA, Ebert BL, Al-Shahrour F, Hasserjian. RP, Scadden EO, Aung Z, Matza M, Markenschlager M, Lin C, Rommens, Scadden DT. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature. 2010 Apr 8;464(7290):852-7. PMID: 20305640

Sykes SM, Lane SW, Bullinger L, Kalatzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme, KM, Acharya SA, Scholl C, Tothova Z, Attar E, Frohling S, DePinho RA, Gilliland DW, Armstrong SA,
Scadden DT. AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell. 2011 Sep2:146(5): 697-708. PMID: 21884932

Krause D, Fulzele K, Catic A, Sun CC, Dombkowski D, Hurley MP, Lezeau S, Attar E, Wu JY, Lin HY, Divieti-Pajevic P, Hasserjian RP, Schipan E, Van Etten RA,
Scadden DT. Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nature Medicine. 2013 Nov ;19(11):1513-7. PMID: 24162813. Featured in Nat Reviews Cancer 2013 13;821

Scadden. Nice Neighborhood: emerging concepts of the stem cell niche. Cell. 2014 Mar 27;157(1):41-50. doi: 10.1016/j.cell.2014.02.013. Review. PMID: 24679525.

Wang YH, Israelsen WJ, Lee D, Yu VW, Jeanson NT, Clish CB, Cantley LC, Vander Heiden MG,
Scadden DT. Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell. 2014 Sep 11;158(6):1309-23.

Yu VW, Saez B, Cook C, Lotinun S, Pardo-Saganta A, Wang YH, Lymperi S, Ferraro F, Raaijmakers MH, Wu JY, Zhou L, Rajagopal J, Kronenberg HM, Baron R,
Scadden DT. Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow.
J Exp Med. 2015 May 4;212(5):759-74.

© 2015 by the President and Fellows of Harvard College