BBS Faculty Member - Pere Puigserver

Pere Puigserver

Department of Cell Biology

Dana Farber Cancer Institute
Center for Life Sciences Building, 11-144
3 Blackfan Circle
Boston, MA 02115
Tel: 617-582-7745
Fax: 617-632-4770
Email: pere_puigserver@dfci.harvard.edu
Lab Members: 5 postdoctoral fellows, 4 graduate students
Visit my lab page here.



Our research interests are on the genetic and biochemical mechanisms underlying the control of intermediary metabolism by nutrients and hormonal signals in mammals. The precise organization and regulation of these metabolic pathways in response to these signals are essential to maintain nutrient and energy homeostasis. Defects in this control will lead to important metabolic abnormalities detected in cancer, aging, diabetes and obesity. The ultimate goal of our research is to understand the coordination, activities and assembly of these biochemical processes and to lay the foundation of new therapies for metabolic diseases, age-associated diseases and cancer.

Our lab focuses on an important biological question: How nutrient and hormonal signals are sensed to control energy and nutrient metabolism in mammals. We study how changes in these signals are sensed and provoke transcriptional responses that induce expression of gene sets linked to energy and nutrient metabolic pathways. We are using mammalian cells as biological models to identify and analyze these signals, transcriptional components, metabolic gene expression and function. Moreover, we systematically analyze the significance of these findings in the energy and nutrient metabolic context of the whole organism in mouse models. We have concentrated in how transcriptional components of the PGC-1 pathway such as SIRT1 and GCN5 sense nutrient and energy signals to control glucose and lipid metabolism. We are in the process of identifying novel components of this regulatory system by using biochemical, genetic, pharmacological and systems biology approaches.



Last Update: 8/22/2013



Publications

For a complete listing of publications click here.

 


 

J.T. Cunningham, J.T. Rodgers, D. Arlow, F. Vazquez, V.K. Mootha and P. Puigserver. The mTOR nutrient pathway controls mitochondrial gene expression and oxidative function through the YY1/PGC-1a transcriptional complex. Nature.2007 Nov 29;450(7170):736-40.

J.T. Rodgers, W. Haas, S.P. Gygi, and P. Puigserver. Cdc2-like Kinase 2 is an insulin regulated suppressor of Hepatic Gluconeogenesis. Cell Metabolism, 2010 11(1), 23-34.

Gerhart-Hines Z, Dominy JE Jr, Blättler SM, Jedrychowski MP, Banks AS, Lim JH, Chim H, Gygi SP, Puigserver P. The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). Molecular Cell. 2011 Dec 23;44(6):851-63.

Blättler SM, Cunningham JT, Verdeguer F, Chim H, Haas W, Liu H, Romanino K, Rüegg MA, Gygi SP, Shi Y, Puigserver P. Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling. Cell Metabolism. 2012 Apr 4;15(4):505-17.



© 2013 by the President and Fellows of Harvard College