BBS Faculty Member - Jeffrey Macklis

Jeffery Macklis

Max and Anne Wien Professor of Life Sciences, Harvard University;
Professor of Stem Cell and Regenerative Biology, Harvard University;
Professor of Neurology and of Neurosurgery, Harvard Medical School




Harvard University
Bauer Laboratory 103
7 Divinity Avenue
Cambridge, MA 02138
Tel: 617-495-5413
Fax: 617-496-9679
Email: jeffrey_macklis@harvard.edu
Lab Members: 7 postdoctoral fellows, 4 graduate students
Visit my lab page here.



Our laboratory is directed toward both 1) understanding molecular controls and mechanisms over neuron sub-type development, diversity, axon guidance-circuit formation, and degeneration in the cerebral cortex (e.g. corticospinal motor neurons - CSMN - in motor neuron disease - ALS, HSPs, and PLS; corticostriatal projection neurons – CStrPN - in Huntington’s disease – HD – and related corticobasal degeneration - CBD), and 2) applying developmental controls toward both brain and spinal cord regeneration (e.g. corticospinal motor neuron (CSMN) circuitry that degenerates in ALS and other “upper motor neuron” degenerative diseases, and whose injury is central to loss of motor function in spinal cord injury) and directed differentiation for in vitro therapeutic and mechanistic screening.

The lab focuses on neocortical projection neuron development and sub-type specification; neural progenitor / “stem cell” biology; induction of adult neurogenesis (the birth of new neurons); subtype-specific axonal growth cone biology; and directed neuronal subtype differentiation via molecular manipulation of neural progenitors and pluripotent cells (ES/iPS). The same biology informs understanding of neuronal subtype specificity of vulnerability of human neurodegenerative and developmental diseases, in particular ALS / motor neuron disease, HSPs, PLS, Huntington's disease, autism spectrum disorders (ASD), and Rett syndrome and ACC in particular of ASDs.



Last Update: 3/3/2015



Publications

For a complete listing of publications click here.

 


 

Magavi SS, Leavitt BR, Macklis JD. Induction of neurogenesis in the neocortex of adult mice. Nature. 2000 Jun 22;405(6789):951-5.

Arlotta P, Molyneaux BJ, Chen J, Inoue J, Kominami R, Macklis JD. Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron. 2005 Jan 20;45(2):207-21.

Molyneaux BJ, Arlotta P, Hirata T, Hibi M, Macklis JD. Fezl is required for the birth and specification of corticospinal motor neurons. Neuron. 2005 Sep 15;47(6):817-31.

Ozdinler PH, Macklis JD. IGF-I specifically enhances axon outgrowth of corticospinal motor neurons. Nat Neurosci. 2006 Nov;9(11):1371-81.

Lai T, Jabaudon D, Molyneaux BJ, Azim E, Arlotta P, Menezes JR, Macklis JD. SOX5 controls the sequential generation of distinct corticofugal neuron subtypes. Neuron. 2008 Jan 24;57(2):232-47.

Joshi PS, Molyneaux BJ, Feng L, Xie X, Macklis JD, Gan L. Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex. Neuron. 2008 Oct 23;60(2):258-72.

Azim E, Jabaudon D, Fame RM, Macklis JD. SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. Nat Neurosci. 2009 Oct;12(10):1238-47.

Czupryn A, Zhou YD, Chen X, McNay D, Anderson MP, Flier JS, Macklis JD. Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science. 2011 Nov 25;334(6059):1133-7.

Cederquist GY, Azim E, Shnider SJ, Padmanabhan H, Macklis JD. Lmo4 establishes rostral motor cortex projection neuron subtype diversity. J Neurosci. 2013 Apr 10;33(15):6321-32.

Greig LC, Woodworth MB, Galazo MJ, Padmanabhan H, Macklis JD. Molecular logic of neocortical projection neuron specification, development and diversity. Nat Rev Neurosci. 2013 Nov;14(11):755-69.

Sadegh C, Macklis JD. Established monolayer differentiation of mouse embryonic stem cells generates heterogeneous, neocortical-like neurons stalled at a stage equivalent to mid-corticogenesis. J Comp Neurol. 2014 Mar 8.



© 2014 by the President and Fellows of Harvard College