BBS Faculty Member - David Livingston

David Livingston

Department of Genetics

Dana-Farber Cancer Institute
Smith Building Room 870
44 Binney Street
Boston, MA 02115
Tel: 617-632-3074
Fax: 617-632-4381
Email: david_livingston@dfci.harvard.edu
Lab Members: 13 postdoctoral fellows, 1 graduate student



The laboratory focuses on attempting to decipher the molecular mechanisms that support the evolution of neoplastic and tumorigenic derivatives of normal human cells. In particular, we have a longstanding investment in attempting to understand how the BRCA1 and BRCA2 breast and ovarian cancer suppressor gene products function in vivo. Recently, we have found new and unexpected functions both for BRCA1 (at stalled replication forks) and for a multi-subunit complex of BRCA1-associated proteins (Rap80 complex) that operates together with BRCA1 p220 in established nuclear organelles, termed ionizing radiation induced foci (IRIF). The Rap80 complex acts in the context of IRIF to down modulate BRCA1 homologous recombination function in the interest of suppressing spontaneous genome plasticity. Furthermore, our most recent results suggest another surprise, namely that a particular BRCA1 isoform (BRCA1-IRIS), a product of alternative BRCA1 splicing, exerts a protooncoprotein function that promotes major elements of tumor progression. Thus, the BRCA1 locus encodes both tumor suppressing and a potential tumor promoting gene product. We have traditionally utilized a variety of genetic, biochemical, and biological methods- to address specific problems in these focused areas of work.



Last Update: 8/22/2013



Publications

For a complete listing of publications click here.

 


 

Sheng Q, Liu, X, Fleming E, Yuan K, Piao H, Chen J, Moustafa Z, Thomas RK, Greulich H, Schinzel A, Zaghlul S, Batt D, Ettenberg S, Meyerson M, Schoeberl B, Kung AL, Hahn WC, Drapkin R, Livingston DM, and Liu JF. An activated ErBB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells. Cancer Cell 2010, Mar 16; 17(3):298-310.

Hu, Y., Scully, R. Sobhian, B., Xie, A., Shestakova, E., and Livingston, D.M. RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci.
Genes and Development. Apr 1;25(7):685-700. Epub 2011 Mar 15.

Pathania, S, Nguyen, J, Hill, S.J., Scully, R., Feunteun, J., and Livingston , D.M. BRCA1 is Required for Post-replication Repair After UV-induced DNA Damage
Mol Cell, in press, 2011



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