BBS Faculty Member - Bruce Levy

Bruce Levy

Department of Internal Medicine
Pulmonary and Critical Care Medicine Division


Brigham and Women's Hospital
HIM Building, Room 855
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: 617-525-5407
Fax: 617-525-5413
Email: blevy@partners.org
Lab Members: 5 postdoctoral fellows, 2 predoctoral students



Research in the Levy Lab focuses on endogenous mechanisms for resolution of lung inflammation and injury. The laboratory’s overall mission is to identify natural small molecule regulators of the severity and duration of innate and adaptive immune responses in the lung and their relationship to human diseases, such as asthma.

Of particular interest are the molecular signaling circuits for autacoids that promote resolution, such as lipoxins, protectins and resolvins from arachidonic acid and the omega-3 fatty acids docosahexaenoic and eicosapentaenoic acid, respectively. In addition, we have laid the groundwork for polyisoprenyl phosphate remodeling to serve as a new counter-regulatory signal transduction pathway in leukocytes and lung parenchymal cells.

Our research also actively translates these basic observations to the genesis of human illness to gain a molecular understanding of the pathobiology of inflammatory lung disease and to use these insights towards new therapeutic strategies for refractory lung diseases, such as acute lung injury/ARDS and severe asthma.


















Last Update: 8/22/2013



Publications

For a complete listing of publications click here.

 


 

Haworth, O, Cernadas, M, Yang, R, Serhan, CN, Levy, BD. Resolvin E1 regulates interleukin-23, interferon-g and lipoxin A4 to promote the resolution of allergic airway inflammation. Nature Immunology. 2008. Aug;9(8):873-9. Epub 2008 Jun 22. PMID: 18568027.

Planaguma A, Kazani S, Marigowda G, Haworth O, Mariani TJ, Israel E, Bleecker ER, Curran-Everett D, Erzurum SC, Calhoun WJ, Castro M, Chung KF, Gaston B, Jarjour NN, Busse WW, Wenzel SE,
Levy BD. Airway LXA4 Generation and LXA4 Receptor Expression are Decreased in Severe Asthma. Am J Respir Crit Care Med. 2008 Sep 15;178(6):574-82. Jun 26. Epub 2008 Jun 26. PMID: 18583575.

Eickmeier O, Seki H, Haworth O, Hilberath JN, Gao F, Uddin M, Croze RH, Carlo T, Pfeffer MA,
Levy BD. Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury. Mucosal Immunology 2012 Jul 11 [Epub ahead of print] PMID: 22785226

Bozinovski S, Uddin M, Vlahos R, Thompson M, McQualter JL, Merritt AS, Wark PA, Hutchinson A, Irving LB,
Levy BD*, Anderson GP.*(*shared senior authorship) Serum amyloid A opposes lipoxin A4 to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease, Proceedings of the National Academy of Sciences of the United States of America. 2012 Jan 17;109(3):935-40. PMID:22215599

Rogerio AP, Haworth O, Croze R, OH SF, Uddin M, Carlo T, Pfeffer MA, Priluck R, Serhan CN,
Levy BD. Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airway responses. Journal of Immunology 2012. July 16 [Epub ahead of print] PMID:22802419



© 2014 by the President and Fellows of Harvard College