BBS Faculty Member - Andrius Kazlauskas

Andrius Kazlauskas

Department of Ophthalmology

The Schepens Eye Research Institute
20 Staniford Street

Boston, MA 02114
Tel: 617-912-2517
Fax: 617-912-0101
Email: andrius_kazlauskas@meei.harvard.edu
Lab Members: 6 postdoctoral fellows, 1 scientific research associate
Visit my lab page here.



My laboratory is contributing to two research areas: intracellular signaling events that govern angiogenesis, and the role of growth factors in human disease.

The angiogenesis projects are developing from our recent discovery of an internal destabilization pathway that controls the stability of blood vessels. We are identifying essential components of this pathway, and assessing their role in the pathogenesis of endemic, blinding conditions such as proliferative diabetic retinopathy and neovascular age-related macular degeneration.

The growth factor projects emanate from our surprising observation that a non-traditional route to activate growth factor receptors is particularly important for the appearance of pathology. These findings have provided new opportunities to develop effective therapeutic strategies and thereby improve health care and the quality of life for patients.














Last Update: 6/4/2014



Publications

For a complete listing of publications click here.

 


 

A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α. Lei H, Kazlauskas A. Mol Cell Biol. 2014 Jan;34(1):110-22. PMID: 24190966

Ranibizumab is a potential prophylaxis for proliferative vitreoretinopathy, a nonangiogenic blinding disease. Pennock S, Kim D, Mukai S, Kuhnle M, Chun DW, Matsubara J, Cui J, Ma P, Maberley D, Samad A, Van Geest RJ, Oberstein SL, Schlingemann RO, Kazlauskas A. Am J Pathol. 2013 May;182(5):1659-70. PMID: 23582767

Regression activity that is naturally present in vitreous becomes ineffective as patients develop proliferative diabetic retinopathy. Aranda J, Motiejunaite R, Silva P, Aiello LP, Kazlauskas A. Diabetologia. 2013 Jun;56(6):1444-53. PMID: 23508305

Vascular endothelial growth factor A competitively inhibits platelet-derived growth factor (PDGF)-dependent activation of PDGF receptor and subsequent signaling events and cellular responses. Pennock S, Kazlauskas A. Mol Cell Biol. 2012 May;32(10):1955-66. PMID: 22431518

Axl is essential for VEGF-A-dependent activation of PI3K/Akt. Ruan GX, Kazlauskas A. EMBO J. 2012 Apr 4;31(7):1692-703. PMID: 22327215

Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression. Im E, Motiejunaite R, Aranda J, Park EY, Federico L, Kim TI, Clair T, Stracke ML, Smyth S, Kazlauskas A. Mol Cell Biol. 2010 PMID: 20231358



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