BBS Faculty Member - Andrius Kazlauskas

Andrius Kazlauskas

Department of Ophthalmology

The Schepens Eye Research Institute
20 Staniford Street

Boston, MA 02114
Tel: 617-912-2517
Fax: 617-912-0101
Email: andrius_kazlauskas@meei.harvard.edu
Lab Members: 6 postdoctoral fellows, 1 scientific research associate
Visit my lab page here.



My laboratory is contributing to two research areas: intracellular signaling events that govern angiogenesis, and the role of growth factors in human disease.

The angiogenesis projects are developing from our recent discovery of an internal destabilization pathway that controls the stability of blood vessels. We are identifying essential components of this pathway, and assessing their role in the pathogenesis of endemic, blinding conditions such as proliferative diabetic retinopathy and neovascular age-related macular degeneration.

The growth factor projects emanate from our surprising observation that a non-traditional route to activate growth factor receptors is particularly important for the appearance of pathology. These findings have provided new opportunities to develop effective therapeutic strategies and thereby improve health care and the quality of life for patients.














Last Update: 8/22/2013



Publications

For a complete listing of publications click here.

 


 

Im E, Kazlauskas A. Regulating angiogenesis at the level of PtdIns-4,5-P(2). EMBO J 2006; 25:2075-82.

Im E,
Kazlauskas A. Src family kinases promote vessel stability by antagonizing the Rho/ROCK pathway. J Biol Chem 2007; 282:29122-9.

Lei H,
Kazlauskas A. Growth factors outside of the PDGF family employ ROS/SFKs to activate PDGF receptor alpha and thereby promote proliferation and survival of cells. J Biol Chem 2009; 284:6329-36. PMC2649107

Im E, Motiejunaite R, Aranda J, Park EY, Federico L, Kim TI, Clair T, Stracke ML, Smyth S,
Kazlauskas A. Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression. Mol Cell Biol 2010; 30:2401-10. PMC2863716

Lei H, Velez G, Cui J, Samad A, Maberley D, Matsubara J,
Kazlauskas A. N-acetylcysteine suppresses retinal detachment in experimental model of proliferative vitreoretinopathy. Am J Pathol. 2010 Jul;177(1):132-40. Epub 2010 May 20.

Lei H, Velez G,
Kazlauskas A. Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. Mol Cell Biol. 2011 May;31(9):1788-99. Epub 2011 Feb 28.



© 2013 by the President and Fellows of Harvard College