BBS Faculty Member - Sekar Kathiresan

Sekar Kathiresan

Department of Medicine

Massachusetts General Hospital
Simches Research Center CPZN 5.830
185 Cambridge St.
Boston, MA 02114
Tel: 617-643-6120
Fax: 617-507-7766
Visit my lab page here.

Sekar Kathiresan, a physician scientist and a human geneticist, is the Director of the Center for Genomic Medicine (CGM) at Massachusetts General Hospital (MGH), Ofer and Shelley Nemirovsky MGH Research Scholar, Director of the Cardiovascular Disease Initiative at the Broad institute, and an Associate Professor of Medicine at Harvard Medical School.

Dr. Kathiresan leverages human genetics to understand the root causes of heart attack and to improve preventive cardiac care. Among his scientific contributions, Dr. Kathiresan has helped highlight new biological mechanisms underlying heart attack, discovered mutations that protect against heart attack risk, and developed a genetic test for personalized heart attack prevention.

Dr. Kathiresan received his B.A. in history and graduated summa cum laude from the University of Pennsylvania in 1992 and received his M.D. from Harvard Medical School in 1997. He then completed his clinical training in internal medicine and cardiology at MGH, where he served as Chief Resident in Internal Medicine from 2002-2003. Dr. Kathiresan pursued research training in cardiovascular genetics through a combined experience at the Framingham Heart Study and the Broad Institute. In 2008, he joined the faculties of the MGH Cardiology Division, Cardiovascular Research Center, and Center for Human Genetic Research.

Last Update: 3/21/2017


For a complete listing of publications click here.



Musunuru K*, Pirruccello JP*, Do R*, Peloso GM, Guiducci C, Sougnez C, Garimella KV, Fisher S, Abreu J, Barry AJ, Fennell T, Banks E, Ambrogio L, Cibulskis K, Kernytsky A, Gonzalez E, Rudzicz N, Engert JC, DePristo MA, Daly MJ, Cohen JC, Hobbs HH, Altshuler D, Schonfeld G, Gabriel SB*, Yue P*, Kathiresan S*. Exome sequencing, mutations in ANGPTL3, and familial combined hypolipidemia. N Engl J Med 2010; 363: 2220-2227. PMID: 20942659 (cited by 102)

Teslovich TM*, Musunuru K*, Global Lipids Genetics Consortium Collaborators, Cupples LA*, Sandhu MS*, Ridker PM*, Rader DJ*, van Duijn CM*, Peltonen L*, Abecasis GR*, Boehnke M*,
Kathiresan S*. Biological, clinical, and population relevance of 95 loci for blood lipids. Nature 2010;466: 707-713. PMID: 20686565 (cited by 574)

Musunuru K*, Strong A*, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JJ, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, Morales CR, Lund-Katz S, Phillips MC, Wong J, Cantley W, Racie T, Ejebe KG, Orho-Melander M, Melander O, Koteliansky V, Fitzgerald K, Krauss RM, Cowan CA,
Kathiresan S* & Rader DJ*. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature 2010;466: 714-719. PMID: 20699424 (cited by 191)

Voight* BF, Peloso* GM, Orho-Melander M, Frikke-Schmidt R, Barbalic M, Jensen MK, Hindy G, Hólm H, Ding EL, Johnson T, Schunkert H, Samani NJ,…, Overvad K, Rimm E, Boerwinkle E, Tybjaerg-Hansen A, Cupples LA, Reilly MP, Melander O, Mannucci PM, Ardissino D, Siscovick D, Elosua R, Stefansson K, O’Donnell CJ, Salomaa V, Rader DJ, Peltonen L, Schwartz SM, Altshuler D,
Kathiresan S. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet 2012;280: 572-580. PMID: 22607825. (cited by 73)

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