BBS Faculty Member - Antoine Karnoub

Antoine Karnoub

Department of Pathology

Beth Israel Deaconess Medical Center
Center for Life Sciences Building, Room 0634
3 Blackfan Circle
Boston, MA 02115
Tel: 617-735-2082
Fax: 617-735-2840
Email: akarnoub@bidmc.harvard.edu



Our laboratory at the Center for Life Sciences is interested in understanding the heterotypic crosstalk that operates between the epithelial and the stromal compartments within carcinomas, with particular emphasis on how these interactions influence cancer metastasis. Our previous work indicated that certain bone-marrow-derived progenitor cells termed mesenchymal stem cells (MSCs) can home specifically to developing neoplasms where they integrate into the tumor stroma. Within this microenvironment, the tumor-associated MSCs become activated, and initiate de novo secretion of chemokines, cytokines, growth factors, and matrix proteins which act on the cancer cells and promote their growth, motility, invasion, and metastasis. The major current efforts of our group are now directed towards (1) deciphering the nature of the cancer-derived systemic signals that affect the bone marrow, and how such interactions mobilize MSCs and cause their recruitment to the tumor microenvironment; (2) characterizing the nature of the heterotypic interactions that cause the activation of MSCs within the tumor stroma, and (3) elucidating the various mechanisms by which MSCs exert their pro-malignant functions.



Last Update: 8/22/2013



Publications

For a complete listing of publications click here.

 


 

Karnoub AE and Weinberg RA. Chemokine networks and breast cancer metastasis. Breast Dis. 2006/7; 26:75-85.

Scheel C, Onder T., Karnoub AE, Weinberg RA. Adaptation versus selection: origins of metastatic behavior. Cancer Res. 2007; 67:11476-11479.

Ince TA, Richardson AL, Bell GW, Saitoh M, Godar S, Karnoub AE, Iglehart JD, Weinberg RA. Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell 2007;12:160-70.

Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007;449:557-63.



© 2013 by the President and Fellows of Harvard College