BBS Faculty Member - Nada Kalaany

Nada Kalaany

Department of Pediatrics

Boston Children's Hospital
Division of Endocrinology, CLS-16067
3 Blackfan Circle
Boston, MA 02115
Tel: 617-919-4896
Fax: 617-730-0244
Email: Nada.Kalaany@childrens.harvard.edu
Visit my lab page here.



A main focus of our lab is to investigate the correlation between systemic metabolism and cancers of different tissues, with the goal of identifying metabolic dependencies that could be targeted therapeutically in cancer patients.

Evidence for a robust correlation between systemic metabolism and cancer incidence and progression has been accumulating for over a century. For instance, the anti-tumorigenic effects of dietary restriction have been recognized since the early 1900s. Moreover, the last three decades witnessed a worldwide epidemic surge of obesity and its associated metabolic syndrome. Multiple epidemiological studies demonstrate a linear correlation between the observed increase in obesity and mortality from cancers of a wide variety of tissues. This correlation has been estimated to account, in the United States, for 14% and 20% of all deaths from cancer in men and women, respectively.

Using in vitro and in vivo models of lung and pancreatic cancer, our lab aims at identifying metabolic dependencies in tumors growing under distinct systemic metabolic states, with the goal of targeting them therapeutically.

In particular, our lab is interested in understanding:

- How tumors survive and thrive in harsh nutrient-limiting environments
- How tumor growth and metabolism can be affected by the systemic metabolic state of the host (i.e. dietary restriction, obesity, insulin resistance)
-How tumor growth can in turn affect the systemic metabolism of the host



Last Update: 1/30/2018



Publications

For a complete listing of publications click here.

 


 



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