BBS Faculty Member - Victor Hsu

Victor Hsu

Department of Medicine

Brigham and Women's Hospital
Smith Bldg., Room 538
One Jimmy Fund Way
Boston, MA 02115
Tel: 617-525-1103
Fax: 617-525-1104
Email: vhsu@rics.bwh.harvard.edu
Lab Members: 3 postdoctoral fellows, 2 instructors



We are interested in understanding mechanisms of intracellular transport and also applying these insights to elucidating physiology and disease mechanisms. Coat proteins initiate, and thereby define, intracellular transport pathways. In recent years, we have been elucidating how key lipids cooperate with coat proteins to form the two general classes of transport carriers, vesicles and tubules. We have also identified a novel coat complex that acts in endocytic recycling, a pathway critical for many cellular events. We have been applying these basic insights to understanding how transport events play critical roles in cell migration, metabolic homeostasis, and viral pathogenesis.








Last Update: 8/22/2013



Publications

For a complete listing of publications click here.

 


 

Bai, M., Gad, H., Turacchio, G., Cocucci, E., Yang, J., Li, J., Beznoussenko, G.V., Nie, Z., Luo, R., Fu, L., Collawn, J.F., Kirchhausen, T., Luini, A., Hsu, V.W. ARFGAP1 promotes AP-2-dependent endocytosis. Nature Cell Biology 2011; 13: 559-67.

Yang, J.S., Valente, C., Polishchuk, R.S., Turacchio, G., Layre, E., Moody, D.B., Leslie, C.C., Gelb, M.H., Brown, W.J., Corda, D., Luini, A., and Hsu, V.W. COPI acts in both vesicular and tubular transport. Nature Cell Biology 2011; 13: 996-1003.

Hsu V.W., Bai, M., and Li, J. Getting active: protein sorting in endocytic recycling. Nature Reviews Molecular Cell Biology 2012; 13:323-8.

Li, J., Malaby, A.W., Famulok, M., Sabe, H., Lambright, D.G., and Hsu, V.W. Grp1 plays a key role in linking insulin signaling to glut4 recycling. Developmental Cell 2012; 22: 1286-98.



© 2013 by the President and Fellows of Harvard College