BBS Faculty Member - Patricia D'Amore

Patricia D'Amore

The Schepens Eye Research Institute
3rd Floor
20 Staniford Street- 2 West
Boston, MA 02114
Tel: 617-912-2559
Fax: 617-912-0128
Email: patricia_damore@meei.harvard.edu
Lab Members: 4 postdoctoral fellows
Visit my lab page here.



The D’Amore laboratory has a long-standing interest in the regulation of vascular development and pathology. One major area has involved investigating the role and regulation of VEGF in adult vascular and non-vascular cells. More recently, her laboratory has been examining the role of inflammation in the pathogenesis of age-related macular degeneration. The laboratory is currently focused in three general areas. Two of those relate to understanding the molecular basis of blood vessel stabilization. One project is examining the role of Notch signaling in the stabilization of the microvasculature and the effect of diabetes on this signaling. A related project is aimed at elucidating other mechanisms that may mediate pericyte stabilization of the capillaries. Studies in both research areas are utilizing genetic model as well as tissues culture systems. A second project is examining a novel endothelial-specific molecule endomucin in the regulation of leukocyte-endothelial interactions, a central and early step in the inflammatory process. A third research focus deals with the contribution of inflammation in the pathogenesis of age-related macular degeneration and involves studying the role of the inflammasome in the retinal pigment epithelium.



Last Update: 7/14/2014



Publications

For a complete listing of publications click here.

 


 

Tamoxifen Toxicity in Cultured Retinal Pigment Epithelial Cells is Mediated by Concurrent Regulated Cell Death Mechanisms. Kim LA, Amarnani D, Gnanaguru G, Tseng WA, Vavvas DG, D'Amore PA. Invest Ophthalmol Vis Sci. 2014 Jul 3. pii: IOVS-13-13662. doi: 10.1167/iovs.13-13662. [Epub ahead of print]

Notch signaling functions in retinal pericyte survival. Joseph F Arboleda-Velasquez, Vincent A Primo, Mark J Graham, Alexandra M James, Jan Manent, and Patricia A. D'Amore. Invest. Ophthalmol. Vis. Sci., Jul 2014; 10.1167/iovs.14-14046.

NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration. Tseng WA, Thein T, Kinnunen K, Lashkari K, Gregory MS, D'Amore PA, Ksander BR. Invest Ophthalmol Vis Sci. 2013 Jan 7;54(1):110-20. doi: 10.1167/iovs.12-10655.

The role of shear-induced transforming growth factor-β signaling in the endothelium. Walshe TE, dela Paz NG, D'Amore PA. Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2608-17. doi: 10.1161/ATVBAHA.113.302161. Epub 2013 Aug 22. PMID: 23968981
[PubMed - indexed for MEDLINE]



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