BBS Faculty Member - Andrew Brack

Andrew Brack

Department of Medicine

Massachusetts General Hospital
Simches Research Center CPZN-4
185 Cambridge St.
Boston, MA 02114
Tel: 617-726-5092
Fax: 617-724-2662
Email: abrack@partners.org
Visit my lab page here.



Our lab interests lie at the interface between adult stem cell biology and tissue regeneration. We focus on the molecular pathways that control cell fate decisions of the adult muscle stem cell (the satellite cell) to effectively regenerate adult skeletal muscle.

We believe that the temporally coordinated cell fate decisions of the stem cell and its progeny are reliant on the communication between the local environment (the muscle stem cell niche) and the stem cell itself. Adult skeletal muscle is capable of rapid repair due to the presence of a potent and essential stem cell, satellite cells, and their microenvironment. Currently, we have active projects in the following areas: satellite cell quiescence and self-renewal, the stem cell niche, satellite cell heterogeneity, aging, and muscle cell size regulation. In the future, we hope our research will lead to strategic improvements in stem cell therapy that target aging and skeletal muscle disease.



Last Update: 8/9/2013



Publications

For a complete listing of publications click here.

 


 

Brack, A.S., Conboy, M.J., Roy, S., Lee, M., Kuo, C., Keller, C., Rando, T.A. (2007) Elevated Wnt signaling during aging alters the fate of myogenic stem cells leading to increased fibrosis and impaired regeneration. Science. 317: 807-810.

Brack, A.S
., Conboy, I.M., Conboy, M.J., Shen, J, and Rando, T.A. (2008) A temporal switch from Notch to Wnt is necessary for normal adult myogenesis. Cell: Stem Cell. 2:
50-59.

Shea, K.L, Xiang, W., LaPorta, V.S., Licht, J.D., Keller, C., Basson, M.A.,
Brack, A.S. (2010) Sprouty1 Regulates Reversible Quiescence of a Self-Renewing Adult Muscle
Stem Cell Pool during Regeneration.
Cell Stem Cell 6: 117-129.

Brack, A.S., Rando, T.A. (2012). Tissue-specific stem cells: lessons from the skeletal muscle satellite cell. Cell Stem Cell 4;10(5): 504-14.

Brack A.S., (2013). Ageing of the heart reversed by youthful systemic factors!. EMBO J. 2013 Jul 16. PMID: 23860129.



© 2013 by the President and Fellows of Harvard College