BBS Faculty Member - Roland Baron

Roland Baron

Professor and Chair, Oral Medicine, Infection and Immunity, HSDM
Professor, Internal Medicine, HMS, Endocrine Unit, MGH

Harvard School of Dental Medicine
188 Longwood Avenue, REB 310
Boston, MA 02115
Tel: 617-432-7320
Fax: 617-432-1897
Email: roland_baron@hms.harvard.edu



The laboratory studies the molecular aspects of the development and maintenance of the skeleton. Project groups focus primarily on different aspects of signal transduction that regulate cell differentiation and function during these processes. One program focuses on the analysis of the signaling mechanisms that are activated by G protein-coupled receptors, receptor tyrosine kinases, and integrins, particularly in the regulation of cell function and the cytoskeleton. The second program focuses on the regulation of mesenchymal stem cell differentiation during skeletal development, and in particular chondrocytes in the growth plate and the osteoblast and adipocyte differentiation and its relationship to metabolism and energy expenditure, including the role of the CNS. The underlying disease models of these programs are mostly osteoporosis, joint diseases and obesity.



Last Update: 8/9/2013



Publications

Horne W.C., Sanjay. A, Bruzzaniti A. and Baron R. The role of Src and Cbl in osteoclast biology. Immunological Reviews 208:106-125, 2005.

Baron R. and Rawadi G. Targeting the Wnt/B-Catenin pathway to regulate bone formation in the adult skeleton. Endocrinology 148: 2635-2643, 2007

Destaing O., Sanjay A., Itzstein C., Horne W.C., Toomre D., De Camilli P. and Baron R. The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts. Mol. Biol. of the Cell , 19:394-404, 2007

Gil-Henn H, Destaing O., Sims N.A., Aoki K., Alles N., Neff L., Sanjay A., Bruzzaniti A., De Camilli P., Baron R. *and Schlessinger Y. *Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2-/- mice. J. Cell Biol. , 178:1053-64, 2007. (* Co-senior authors)



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