BBS Faculty Member - Haribabu Arthanari

Haribabu Arthanari

Department of Biological Chemistry and Molecular Pharmacology

Harvard Medical School
Longwood Center, LC-3311
360 Longwood Ave.
Boston, MA 02115
Tel: 617-632-6422
Email: hari@hms.harvard.edu
Visit my lab page here.



Protein-Protein Interactions (PPIs) is the Holy Grail of therapeutic intervention, offering a plethora of distinct structural landscapes that can be targeted with high specificity. Arthanari lab uses structure-guided approaches to characterize and validate these interactions in the context of disease models.  We utilize a combination of techniques including NMR spectroscopy, high throughput screening, and biophysical and cell-based assays to map hotspots in the interaction interface, to further understand the molecular mechanisms orchestrated by these interactions, and to identify disruptive inhibitors that may be developed into treatments for the related pathologies. Our current areas of focus are 1) the critical interactions between transcription factors and the general transcriptional machinery, including the Mediator complex, co-activators, and remodeling factors, and 2) translation initiation machinery demonstrated to be dysregulated in cancer disease states.  Our work on novel NMR methods let us push the boundaries of NMR as a technique, allowing us to tackle larger and complex systems by NMR. We also develop NMR methods to dissect and uncover the secrets of the disordered part of the human proteome referred to as the “Dark Proteome"






























Last Update: 8/17/2016



Publications

For a complete listing of publications click here.

 


 

Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction. Nishikawa JL, Boeszoermenyi A, Vale-Silva LA, Torelli R, Posteraro B, Sohn YJ, Ji F, Gelev V, Sanglard D, Sanguinetti M, Sadreyev RI, Mukherjee G, Bhyravabhotla J, Buhrlage SJ, Gray NS, Wagner G, Näär AM, Arthanari H. Nature. 2016 Feb 25;530(7591):485-9.

Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication. Leigh KE, Sharma M, Mansueto MS, Boeszoermenyi A, Filman DJ, Hogle JM, Wagner G, Coen DM,Arthanari H. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9010-5. 

A new broadband homonuclear mixing pulse for NMR with low applied power. Coote P, Leigh KE, Yu TY, Khaneja N, Wagner G, Arthanari H. J Chem Phys. 2014 Jul 14;141(2):024201. 
  
Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase. Frueh DP, Arthanari H, Koglin A, Vosburg DA, Bennett AE, Walsh CT, Wagner G.
Nature. 2008 Aug 14;454(7206):903-6. 

A nuclear receptor-like pathway regulating multidrug resistance in fungi. Thakur JK*, Arthanari H*, Yang F*, Pan SJ, Fan X, Breger J, Frueh DP, Gulshan K, Li DK, Mylonakis E, Struhl K, Moye-Rowley WS, Cormack BP, Wagner G, Näär AM. Nature. 2008 Apr 3;452(7187):604-9 * (co-first authors)



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