Paul Anderson
Division of Rheumatology, Immunology and Allergy
Brigham and Women's Hospital
Smith Building Room 652C
One Jimmy Fund Way
Boston, MA 02115
Tel: (617) 525-1202
Fax: (617) 525-1310
Email: panderson@rics.bwh.harvard.edu
Web Page: The Anderson Lab Page
Messenger RNA is in constant flux between different locations and states-- the nucleus and cytoplasm, activation and silencing, translation and decay. Classical nuclear bodies such as nucleoli and nuclear speckles are self-generated RNA structures whose morphology and function are inextricably linked: altered morphology reflects altered function. Cytoplasmic RNA structures such as stress granules (SGs) and processing bodies (PBs) have been revealed as functional byproducts of mRNA metabolism. Stress granules (SGs) and processing bodies (PBs) share substrate mRNA, dynamic properties and many proteins, but also house separate components and independent functions. Each can exist without the other, but when coordinately induced they are often tethered together in a cytosolic dance. Work in the laboratory is focused on understanding the role of subcellular localization in the control of mRNA translation/decay.
References:
- Emara MM, Ivanov P, Hickman T, Dawra N, Tisdale, S, Kedersha N, Guo-Fu H, Anderson P. Angiogenin-induced tiRNAs promote stress-induced stress granule assembly. J Biol Chem 2010 285:10959
- Simarro M, Giannattasio G, Fuente MA, Benarafa C, Subramanian KK Ishizawar R, Andersson EM, Luo HR, Orduna A, Boyce J, Anderson P. Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation. J Immunol 2010 184:5325
- Li C-H, Ohn T, Ivanov P, Tisdale S, Anderson P. eIF5A promotes translation elongation, polysome disassembly and stress granule assembly. PLoS ONE 2010 5:e9942
- Anderson P. Post-transcriptional regulons coordinate the initiation and resolution of inflammation [review]. Nat Rev Immunol 2010 Jan 10; (1):24-35.
For a complete listing of publications on PubMed, click here.
BBS webpage updated 5/18/2010