Biological and Biomedical Science
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Paul Anderson

Division of Rheumatology, Immunology and Allergy
Brigham and Women's Hospital
Smith Building Room 652C

One Jimmy Fund Way
Boston, MA 02115
Tel: (617) 525-1202
Fax: (617) 525-1310
Email: panderson@rics.bwh.harvard.edu
Web Page: The Anderson Lab Page

Paul Anderson

Messenger RNA is in constant flux between different locations and states-- the nucleus and cytoplasm, activation and silencing, translation and decay. Classical nuclear bodies such as nucleoli and nuclear speckles are self-generated RNA structures whose morphology and function are inextricably linked: altered morphology reflects altered function. Cytoplasmic RNA structures such as stress granules (SGs) and processing bodies (PBs) have been revealed as functional byproducts of mRNA metabolism. Stress granules (SGs) and processing bodies (PBs) share substrate mRNA, dynamic properties and many proteins, but also house separate components and independent functions. Each can exist without the other, but when coordinately induced they are often tethered together in a cytosolic dance. Work in the laboratory is focused on understanding the role of subcellular localization in the control of mRNA translation/decay.

 

References:

  • Ohn T, Kedersha N, Hickman T, Tisdale S, Anderson P. A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly. Nat Cell Biol 2008 Oct; 10(10):1224-31.
  • Anderson P. Post-transcriptional control of cytokine production. Nat Immunol 2008 Apr; 9(4):353-9.
  • Yamasaki S, Anderson P. Reprogramming mRNA translation during stress. Curr Opin Cell Biol 2008 Apr; 20(2):222-6.
  • Anderson P. Intrinsic mRNA stability helps compose the inflammatory symphony Nat Immunol 2009 Mar; 10(3):233-4.
  • Anderson P, Kedersha N. RNA granules: post-transcriptional and epigenetic modulators of gene expression. Nature Reviews/Molecular Cell Biology 2009 ;10: 430-6.
  • Anderson P, Kedersha N. Stress granules. Current Biology 2009; 10(10):R397-8
  • Yamasaki S, Ivanov P, Hu G, Anderson P. Angiogenin cleaves tRNA and promotes stress-induced translational repression. J Cell Biol 2009; 185: 35-42.