BIG Courses

 

G1 Fall – Required Courses

 

BBS Course - Genetics 201: Principles of Genetics

Faculty: Fred Winston (Medical School), Maxwell G. Heiman (Medical School), Ann Hochschild (Medical School), Mitzi I. Kuroda (Medical School), and Steven A. McCarroll (Medical School)


Description: An in-depth survey of genetics, beginning with basic principles and extending to modern approaches and special topics. We will draw on examples from various systems, including yeast, Drosophila, C. elegans, mouse, human and bacteria.

 

BBS Course - BBS 230: Analysis of the Biological Literature
Faculty:
Adrian Salic (Medical School), Welcome W. Bender (Medical School), Michael Demian Blower (Medical School), et al.


Description: Students participate in intensive small group discussions focused on the critical analysis of basic research papers from a wide range of fields including biochemistry, cell and developmental biology, genetics, and microbiology. Papers are discussed in terms of their background, significance, hypothesis, experimental methods, data quality, and interpretation of results. Students will be asked to propose future research directions, to generate new hypotheses and to design experiments aimed at testing them.

 

BIG Course - Biophysics170/HST508: Quantitative Genomics
Faculty: Shamil R. Sunyaev (Medical School), Isaac S. Kohane (Medical School), Leonid Mirny (Medical School), and members of the Committee


Description: In-depth study of genomics: models of evolution and population genetics; comparative genomics: analysis and comparison; structural genomics: protein structure, evolution and interactions; functional genomics, gene expression, structure and dynamics of regulatory networks.

 

G1 Spring – Required Courses

 

BBS Course - BCMP 201: Biological Macromolecules: Structure, Function and Pathways
Faculty:
Stephen C. Blacklow (Medical School), Gaudenz Danuser (Medical School), Stephen C. Harrison (Medical School), and Peter K. Sorger (Medical School)


Description: Macromolecular structure with emphasis on biochemistry , interactions and catalysis in cellular processes and pathways. Links between theory and observation will emerge from discussion of fundamental principles, computational approaches and experimental methods.

 

BIG Course - GSAS Biophysics205/HST509: Computational and Functional Genomics
Faculty
:Martha L. Bulyk (Medical School), Suzanne Gaudet (Medical School), and Shamil R. Sunyaev (Medical School)


Description: Experimental functional genomics, computational prediction of gene function, and properties and models of complex biological systems. The course will primarily involve critical reading and discussion rather than lecture.



G2 Fall – Required Courses

 

BBS Course - BCMP 200: Molecular Biology
Faculty:
Richard Ian Gregory (Medical School), Kami Ahmad (Medical School), Paul J. Anderson (Medical School), Joseph John Loparo (Medical School), Johannes Walter (Medical School), and Timur Yusufzai (Medical School)


Description: An advanced treatment of molecular biology's Central Dogma. Considers the molecular basis of information transfer from DNA to RNA to protein, using examples from eukaryotic and prokaryotic systems. Lectures, discussion groups, and research seminars.

 

BIG Course – BMI701: Introduction to Biomedical Informatics
Faculty:
Alexa T. McCray (Medical School)


Description: This is an introductory course that surveys methods in biomedical informatics, including methods and approaches used in clinical informatics, bioinformatics, imaging and population health informatics.

 

G2 Spring – Required Courses

 

BIG Course – BMI702: Introduction to Biomedical Informatics
Faculty:
Alexa T. McCray (Medical School)


Description: This is an introductory course surveys methods in biomedical informatics, including methods and approaches used in clinical informatics, bioinformatics, imaging and population health informatics.


Throughout G2 – 2 BIG Electives

Fall (additional courses are available)

 

BIG Course - HSPH BIO513:Advanced Computational Biology & Bioinformatics
Faculty
: Guocheng Yuan and Winston Hide


Description: Students will explore current topics in computational biology in a seminar format with a focus on interpretation of `omics data. They will develop skills necessary for independent research using computational biology.

 

BIG Course - BMI721: Translational Bioinformatics
Faculty
: Isaac Kohane (Medical School)


Description: Translational Bioinformatics is the intellectual toolkit required for the analytic transformation and optimization of the growing mass of high throughput data (genomic and clinical) into diagnostics and therapeutics for medicine. This introductory course will interleave didactic sessions with hands on workshop and a final project. It will cover topics in genome-scale measurements in molecular biology, functional genomics, and relevant bioinformatics toolkits. There will be a weekly practicum associated with this course.

 

Spring (additional courses are available)

 

BIG Course - MIT - 6.881 Computational Personal Genomics
Faculty
: Manolis Kellis (MIT)


Description: This course is aimed at exploring the computational challenges associated with interpreting how sequence differences between individuals lead to phenotypic differences such as gene expression, disease predisposition, or response to treatment.

 

BIG Course - BMI714:Introduction to Next-Generation Sequencing: Methods, Analysis, and Applications
Faculty:
Peter Tonellato (Medical School), Peter Park (Medical School), Dennis Wall (Medical School)

 

Description:  In this course, Introduction to Bioinformatics, students will learn the soups-to-nuts technical, computational, algorithmic and biomedical knowledge databases, genetic variant information systems, and ontology and related resources and tools to conduct practical genome-wide analysis, annotation and interpretation of NGS data.