BBS Faculty Member - Donald Ingber

Donald Ingber

Director, Wyss Institute for Biologically Inspired Engineering at Harvard
Judah Folkman Professor of Vascular Biology, HMS/Boston Childrens Hospital
Professor of Bioengineering, Harvard John A. Paulson School of Engineering and Applied Sciences

Wyss Institute
Center for Life Sciences Building
3 Blackfan Circle, 5th Floor
Boston, MA 02115
Tel: 617-432-7044
Fax: 617-432-7828
Lab Members: 19 postdoctoral fellows, 1 graduate student

My laboratory is interested in how microenvironmental cues, particularly mechanical forces and extracellular matrix, regulate tissue development, physiology and pathology. Our work covers a wide range from fundamental studies of the molecular basis of cellular mechanotransduction to engineering of microdevices and nanotechnologies for basic research, as well as clinical diagnostics and therapeutics. A major effort is now focused on development of “Biomimetic Microsystems” that use methods of miniaturization originally developed to make microchips for the computer industry to build functional circuits with living cells as components. We currently are building tiny, complex, three-dimensional models of human organs that can be used to treat patients, as well as replace costly and time-consuming animal studies for drug development and toxicology applications. Additional studies focus on mechanical mechanisms of control of angiogenesis, organogenesis and tumor development, with the goal of developing biomimetic materials that can promote organ regeneration and reverse cancer when implanted or injected in vivo.

Last Update: 8/7/2015


For a complete listing of publications click here.



Brock A, Krause S, Li H, Kowalski M, Goldberg MS, Collins JJ, Ingber DE.Silencing HoxA1 by Intraductal Injection of siRNA Lipidoid Nanoparticles Prevents Mammary Tumor Progression in Mice. Sci. Trans. Med. 2014; 6:217ra2.

Torisawa Y, Spina CS, Mammoto T, Mammoto A, Weaver JC, Tat T, Collins JJ, Ingber DE. Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro.
Nature Methods 2014; 11:663-9.

Hashmi B, Zarzar L, Mammoto T, Mammoto A, Jiang A, Aizenberg J, and Ingber DE. Developmentally­ Inspired Shrink-Wrap Polymers for Induction of Tissue Differentiation.
Adv. Materials 2014; 26: 3253-3257.

© 2015 by the President and Fellows of Harvard College