George M. Church
Department of Genetics
New Research Building, Room 238
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: 617-432-7562
Fax: 617-432-6513
Lab Members: 18 postdoctoral fellows, 14 graduate students
Visit my lab page here.
Our research focuses on new technologies for genomic & proteomic measurement, synthesis and modeling of biomedical & ecological systems -- in particular, personal genomics and biofuels. We have developed next-generation sequencing methods to analyze the output of combinatorial selections as well as comprehensive gene-environment-trait data for affordable personalized medicine. We reprogram human skin-derived pluripotent skin cells to connect cis-regulatory motif variants in populations to allele-specific and cell-type-specific RNA measures and further to causal effects on cell and larger-scale morphologies. We are developing tools for connecting functional microbiomics with (VDJ-ome) immune responses.
References:
Li JB, Levanon EY, Yoon J-K, Aach J, Xie B, LeProust E, Zhang K, Gao Y, Church GM (2009) Genome-wide Identification of Human RNA Editing Sites by Massively Parallel DNA Capturing and Sequencing. Science. 2009 May 29;324(5931):1210-3.
Wang HH, Isaacs FJ, Forest CR, Sun ZZ, Xu G, Church GM (2009) Multiplexed Genome Engineering and Directed Evolution. Nature in press
Ball MP, Li JB, Gao Y, Lee JH, LeProust EM, Park IH, Xie B, Daley GQ, Church GM. Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol. 2009 Apr;27(4):361-8.
Dantas G, Sommer MO, Oluwasegun RD, Church GM. Bacteria subsisting on antibiotics. Science. 2008 Apr 4;320(5872):100-3.
For a complete listing of publications click here.
Last Update: 2/25/2013