BBS Faculty Member - Jessica L. Whited

Jessica L. Whited

Department of Orthopedic Surgery

Brigham and Women's Hospital
65 Landsdowne St., Room 283
Cambridge, MA 02139
Tel: 617-768-8422
Email: jwhited@partners.org
Visit my lab page here.



Humans and other mammals have extremely limited regenerative capabilities in key parts such as limbs. Nearly two million Americans are currently living with the consequences of having undergone limb amputation due to injury or disease, and this number is expected to rise. No biological therapeutic has been devised to address this problem. In contrast, many salamanders can replace entire lost limbs throughout life, and these limbs are anatomically similar to human limbs. While salamander limb regeneration has been known for centuries, much of the mechanistic detail at the molecular level has remained elusive. A crucial question is how salamanders use the blastema, a collection of relatively dedifferentiated cells derived from stump tissues such as muscle and bone, to orchestrate the regeneration of an entire limb. Using a blastema to regenerate a new limb is a remarkable feat of natural cellular reprogramming. Mammals do not respond to amputation by creating blastemas, and this difference may underlie their inability to regenerate. In the Whited lab, we are studying limb regeneration in axolotls, a species of salamander for which we--and others--have recently developed critical molecular biological tools. We aim to understand the molecular mechanisms that enable the formation, growth, and differentiation state of the axolotl blastema so that this insight can later be used to understand why mammals cannot regenerate limbs.



Last Update: 1/28/2014



Publications

For a complete listing of publications click here.

 


 

Whited, J. L., Tsai, S. T., Beier, K. T., White, J. N., Piekarski, N., Hanken, J., Cepko, C. L., and Tabin, C. J. Pseudotyped retroviruses for infecting axolotl cells in vitro and in vivo. Development, 140(5):1137-46.

Whited, J. L.*, Lehoczky, J. A.*, and Tabin, C. J. 2012. Inducible genetic system for the axolotl.
Proceedings of the National Academy of Science, 109(34):13662-7. *equal contribution

Whited, J. L., Lehoczky, J. A., Austin, C. A., and Tabin, C. J. 2011. Dynamic expression of two Thrombospondins during axolotl limb regeneration.
Developmental Dynamics, 240(5):1249-1258.

Whited, J. L., Robichaux, M. B., Yang, J. C., and Garrity, P. A. 2007. Ptpmeg is required for proper extablishment and maintenance of axonal projections in the central brain of Drosophila.
Development, 134(1):43-53.



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