BBS Faculty Member - Marc Vidal

Marc Vidal

Department of Genetics

Dana Farber Cancer Institute
Smith Bldg., Rm. 858A
450 Brookline Ave.
Boston, MA 02215
Tel: 617-632-5114
Fax: 617-632-5739
Email: marc_vidal@dfci.harvard.edu
Lab Members: 10 postdoctoral fellows, 2 graduate students
Visit my lab page here.



Within cells macromolecules form complex intertwined networks of functionally interacting components. The molecular mechanisms underlying biological processes correspond to particular steady states adopted by such cellular networks. Systems-level theoretical conjectures about cellular networks have remained thin, largely because of lack of supporting experimental data.

To address how complex cellular networks relate to biology, we undertake, at the scale of the whole proteome, integrated approaches for mapping protein-protein interaction or “interactome” networks. The questions we face are: How are interactome networks organized at the scale of the whole cell? How can local and global features underlying this organization be uncovered? How are interactome networks disrupted in human disease, such as cancer?




















Last Update: 10/28/2016



Publications

For a complete listing of publications click here.

 


 

Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabási AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA^, Hill DE^, Hao T^, Roth FP*, Vidal M*. A proteome-scale map of the human interactome network. Cell 2014;159:1212-26 (^ = co-senior authors; * = co-corresponding authors).

Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kovács IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barabási AL, Charloteaux B, Hill DE, Hao T, Roth FP^, Xia Y^, Walhout AJ^, Lindquist S^*,
Vidal M^*. Widespread macromolecular interaction perturbations in human genetic disorders. Cell. 2015;161:647-60 (^ = co-senior authors; * = co-corresponding authors.

Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP^, Hill DE^, Iakoucheva LM^*, Xia Y^*,
Vidal M^*. Widespread expansion of protein interaction capabilities by alternative splicing. Cell 2016;164:805-17 (^ = co-senior authors; * = co-corresponding authors).



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