BBS Faculty Member - Gregory Verdine

Gregory Verdine

Department of Stem Cell and Regenerative Biology

Harvard University
Dept. of Stem Cell and Regenerative Biology
12 Oxford Street
Cambridge, MA 02138
Tel: 617-495-5323
Fax: 617-495-8755
Email: gregory_verdine@harvard.edu
Visit my lab page here.



The research interests of the Verdine lab lie in the emerging area of chemical biology. We study biologic processes underlying growth and proliferation of human cancer cells, control of gene expression, and preservation of genomic integrity. Our research has led to the invention of new and powerful approaches for the discovery of unconventional bioactive ligands termed "synthetic biologics" that have proven effective at addressing therapeutic targets previously considered "undruggable."

Verdine and coworkers have elucidated the mechanism by which DNA methyltransferases catalyze epigenetic modification of the genome, as well as the structural basis for sequence specific DNA recognition by NF-κB and NFAT, master regulators of acute phase and immune responses and organ development.? Our work has illuminated the biochemical and structural basis for enzymatic recognition and removal of mutagenic damage in DNA.



Last Update: 8/22/2013



Publications

For a complete listing of publications click here.

 


 



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