BBS Faculty Member - Kevin Struhl

Kevin Struhl

Department of Biological Chemistry and Molecular Pharmacology

Harvard Medical School
BCMP, C2-315
240 Longwood Avenue
Boston, MA 02115
Tel: 617-432-2104
Fax: 617-432-2529
Email: kevin@hms.harvard.edu
Lab Members: 10 postdoctoral fellows, 1 graduate student
Visit my lab page here.



Transcriptional regulation in response to environmental and developmental cues is mediated by the combinatorial and synergistic action of specific DNA-binding activators and repressors on components of the general transcription machinery and chromatin modifying activities, and it also involves microRNAs. We combine genetic, molecular, genomic, and evolutionary approaches to address fundamental questions about transcriptional regulatory mechanisms in yeast as well as elucidating the transcriptional regulatory circuits that mediate the process of cellular transformation and formation of cancer stem cells.

Relationship between transcriptional regulatory mechanisms and chromatin structure in yeast: Current projects include 1) how co-activators, chromatin-modifying complexes, repressors, and components of the basic transcription machinery are recruited to promoters in vivo under genetically and environmentally defined conditions, 2) intrinsic and dynamic aspects of chromatin structure, and mechanisms of epigenetic inheritance of heterochromatic and euchromatic states, 3) distinguishing between biological function and biological noise using evolutionarily related yeast species and other approaches.

Transcriptional regulatory circuits during the process of cellular transformation in human cells: Current projects include 1) an epigenetic switch from non-transformed to transformed cells in response to a transient inflammatory signal, 2) molecular pathways required for the formation of cancer stem cells, 3) role of microRNAs at various stages of cellular transformation including potential connections to chromatin, 4) mechanistic analysis of the connection between lipid metabolism and transformation, 5) testing metformin as a potential anti-cancer drug.



Last Update: 6/2/2014



Publications

For a complete listing of publications click here.

 


 

Iliopoulos, D., Hirsch, H.A., and Struhl, K. (2009). An epigenetic switch involving NF-B, Lin28, Let-7 microRNA, and IL6 links inflammation to cell transformation. Cell 139 693-706.

Hirsch, H.A., Iliopoulos, D., Joshi, A., Zhong, Y., Jaeger, S.A., Bulyk, M.L, Tsichlis, P.N., Liu, X.S., and Struhl, K. (2010). A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases.
Cancer Cell 17 348-361.

Iliopoulos, D., Hirsch, H.A., Wang, G., and Struhl, K. (2011). Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion.
Proc. Natl. Acad. Sci. U.S.A. 108 1397-1402.

Miotto, B. and Struhl, K. (2011). JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress.
Mol. Cell. 44 62-71.

Wong, K.H. and Struhl, K. (2011). The Cyc8-Tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting protein.
Genes Dev. 25 2525-2539.

Hughes, A., Jin, Y., Rando, O.J., and Struhl, K. (2012). A functional evolutionary approach to identify determinants of nucleosome positioning: A unifying model for establishing the genome-wide pattern.
Mol. Cell 47 in press.



© 2013 by the President and Fellows of Harvard College