BBS Faculty Member - Matthew Steinhauser

Matthew Steinhauser

Department of Medicine

Brigham and Women's Hospital
New Research Building, Room 458C
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: 617-525-4716
Email: msteinhauser@partners.org



The Steinhauser lab is broadly interested in the role of tissue specific progenitors in tissue homeostasis and disease. A key area of focus is on the relationship between adipose tissue plasticity -- including depot-, age-, and context-specific generation of white adipocytes -- and susceptibility to diabetes. The lab developed stable isotope methodology to quantitatively track adipogenesis, in vivo, using measurements of adipogenesis as a basis for screens aimed at identifying novel mediators of fat cell development. In addition, there is a strong focus on using a range of techniques to manipulate the adipocyte pool in the obese state, including using genetically engineered mice, viral gene transfer approaches, and cell/tissue transplantation. The central goal of all of the projects in the lab is to (i) identify novel associations between cellular/molecular pathways and obesity related diabetes and (ii) test these associations for causality.

A strong secondary interest in the lab is continued investment in the development of mass spectrometry based approaches to study progenitor activity and cell turnover. These strategies involve in vivo labeling studies with stable isotope tracers and their subsequent measurement in cells and tissues with either isotope ratio mass spectrometry (IRMS) of bulk samples or multi-isotope imaging mass spectrometry (MIMS) to quantify and image cell turnover and metabolism with sub-organelle resolution. An important rationale for this effort is the possibility of detecting/measuring processes that may be inaccessible with more traditional approaches, while also providing a quantitative platform to guide “screens” to identify candidate disease pathways that can then be interrogated with traditional molecular approaches.

Finally, the lab has a translational arm aimed at testing hypotheses generated in rodent studies with human studies. The lab is currently conducting two human investigations of human adipose tissue plasticity in collaboration with members of the clinical research community at HMS affiliated hospitals.



Last Update: 6/3/2014



Publications

For a complete listing of publications click here.

 


 

Loffredo FS*, Steinhauser ML*, J Gannon, RT Lee. Bone-marrow derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair. Cell Stem Cell 2011; 8: 389-398. *equal contributors

Steinhauser ML, A Bailey, SE Senyo, C Guillermier, TS Perlstein, AP Gould, RT Lee, CP Lechene. Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism. Nature 2012; 481: 516-519.

Senyo SE,
Steinhauser ML, CL Pizzimenti, VK Yang, L Cai, M Wang, T Wu, J Guerquin-Kern, CP Lechene, RT Lee. Mammalian heart renewal by preexisting cardiomyocytes. Nature 2013; 493: 433-436.

Loffredo FS,
Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall’Osso C, Khong D, Shadrach JL, Miller CM, Singer BS, Stewart A, Psychogios N, Gerszten RE, Hartigan AJ, Kim MJ, Serwold T, Wagers AJ, Lee RT. Growth differentiation factor 11 is a
circulating factor that reverses age-related cardiac hypertrophy. Cell 2013; in press.



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