BBS Faculty Member - Jen Sheen

Jen Sheen

Department of Genetics

Massachusetts General Hospital
Simches Research Building CPZN7250
185 Cambridge St
Boston, MA 02114
Tel: 617-726-5916
Fax: 617-726-6893
Email: sheen@molbio.mgh.harvard.edu
Lab Members: 15 postdoctoral fellows
Visit my lab page here and here.



Our laboratory studies the cellular and molecular mechanisms underlying plant responses to central growth and developmental regulators, such as glucose, energy, hormones and stresses, as well as pathogenic suppressors and microbial elicitors of host immunity. We are especially interested in developing simple and powerful assays to systematically explore plant genome resources and uncover novel plant gene functions. We have used an integrated approach, by combining genomic, cellular, biochemical, genetic, proteomic and bioinformatic tools, to discover key regulatory genes and molecules that control diverse plant signal transduction pathways. Our recent studies are unraveling the molecular and biochemical nature of receptors/sensors and signaling cascades and regulatory circuitry that mediate responses to glucose, energy, stress, cytokinin, auxin, abscisic acid, ethylene, and microbe-associated molecular patterns in plant innate immunity. We are currently interested in integrating signaling networks in whole plants from embryogenesis to senescence.



Last Update: 6/19/2014



Publications

For a complete listing of publications click here.

 


 

Xiong, Y., McCormack, M., Hall, Q., Xiang, C.B., and Sheen, J. 2013. Glucose-TOR signalling reprograms the transcriptome and activates meristems. Nature 496: 181-186.

Lee, H., Chah, O.K., and
Sheen, J. 2011. Stem cell immunity activated by CLV3p-FLS2 signaling. Nature 473: 376-379.

Boudsocq, M., Willman, M., McCormack, M., Lee, H., Shan, L., He., P., Bush, J., Cheng, S.H., and
Sheen, J. 2010. Differential innate immune signalling via Ca2+ sensor protein kinases. Nature 464: 418-422.

Yoo, S.D., Cho, Y.H., Tena, G., Xiong, Y., and
Sheen, J. 2008. Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling. Nature. 451: 789-795. PMID: 18273012



© 2014 by the President and Fellows of Harvard College