Department of Developmental Biology
Developmental Biology, REB 510
188 Longwood Ave
Boston, MA 02115
Bone morphogenetic proteins (BMPs), members of the TGF-b gene superfamily, are involved in the formation of nearly all vertebrate organs and tissues. BMP activity is tightly controlled during embryonic development, and increasing or decreasing BMP signaling has significant physiological effects throughout the lifetime of an organism. Research in my lab is focused on understanding how BMPs affect development and maintenance of the musculoskeletal system (bone, cartilage, tendon, ligament and meniscus), tissues in which BMP activity is linked with the ability to undergo regeneration.
Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, and Wang EA. Novel regulators of bone formation: molecular clones and activities. Science 1988;242: 1528-1534.
Wolfman NM, Hattersley G, Celeste AJ, Nelson R, Yamaji N, Dube JL, DiBlasio-Smith E, Nove J, Song JJ, Wozney JM, and Rosen V. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-b gene family. J Clin Investig 1997; 100: 1-10.
Yi SE, Daluiski A, Pederson R, Rosen V, Lyons KM. The type I BMPRIB is required for chondrogenesis in the mouse limb. Development 2000; 127(3):621-30.
Dailuski A, Engstrand T, Bahamonde M, Tompkinson K, Gamer LW, Rosen V, and Lyons KM. BMP3 is a negative regulator of bone density. Nature Genet 2001; 27: 84-88.
Gamer LW, Cox KA, Small C, and Rosen V. Gdf11 is a negative regulator of chondrogenesis and myogensis in the developing chick limb. Dev Biol 2001; 229: 407-420.
Tsuji K, Bandyopadhyay A, Harfe BD, Cox KA, Kakar S, Gerstenfeld L, Einhorn T, Tabin CJ, and Rosen, V. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet. 2006; 38: 1424-1429.
Tsuji K, Bandyopadhyay A, Harfe BD, Cox KA, Tabin CJ, and Rosen V. BMP4 is dispensible for skeletogenesis and fracture healing in the limb. J Bone Joine Surg, 2008; 90: 14-18.
Gamer LW, Ho V, Cox K, Rosen, V. Expression and function of BMP3 during chick limb development. Dev Dyn 2008; 237: 1691-8
Gamer LW, Cox K, Carlo JM, Rosen V. Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fractures. Dev Dyn 2009; 238: 2374-8.
Tsuji K, Cox K, Gamer LW, Gaf D, Economides A, Rosen V. Conditional deletion of BMP7 from the limb does not affect bone formation or fracture repair. J Orthop Res 2010; 28: 384-9.
Gamer LW, Tsuji K, Cox K, Capelo LP, Lowery J, Beppu H, Rosen V. BMPR-II is dispensible for formation of the limb skeleton. Genesis 2011; May 2
For a complete listing of publications click here.
Last Update: 7/26/2012