BBS Faculty Member - Vicki Rosen

Vicki Rosen

Department of Developmental Biology

Harvard School of Dental Medicine
Developmental Biology, REB 510
188 Longwood Ave
Boston, MA 02115
Tel: 617-432-5910
Fax: 617-432-3246
Email: vicki_rosen@hsdm.harvard.edu



Bone morphogenetic proteins (BMPs), members of the TGF-β gene superfamily, are involved in the formation of nearly all vertebrate organs and tissues. BMP activity is tightly controlled during embryonic development, and increasing or decreasing BMP signaling has significant physiological effects throughout the lifetime of an organism. Research in my lab is focused on understanding how BMPs affect development and maintenance of the musculoskeletal system (bone, cartilage, tendon, ligament and meniscus), tissues in which BMP activity is linked with the ability to undergo regeneration.



Last Update: 6/18/2014



Publications

For a complete listing of publications click here.

 


 

Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, and Wang EA. Novel regulators of bone formation: molecular clones and activities. Science 1988;242: 1528-1534.

Wolfman NM, Hattersley G, Celeste AJ, Nelson R, Yamaji N, Dube JL, DiBlasio-Smith E, Nove J, Song JJ, Wozney JM, and Rosen V. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-b gene family. J Clin Investig 1997; 100: 1-10.

Yi SE, Daluiski A, Pederson R, Rosen V, Lyons KM. The type I BMPRIB is required for chondrogenesis in the mouse limb. Development 2000; 127(3):621-30.

Dailuski A, Engstrand T, Bahamonde M, Tompkinson K, Gamer LW, Rosen V, and Lyons KM. BMP3 is a negative regulator of bone density. Nature Genet 2001; 27: 84-88.

Gamer LW, Cox KA, Small C, and Rosen V. Gdf11 is a negative regulator of chondrogenesis and myogensis in the developing chick limb. Dev Biol 2001; 229: 407-420.

Tsuji K, Bandyopadhyay A, Harfe BD, Cox KA, Kakar S, Gerstenfeld L, Einhorn T, Tabin CJ, and Rosen, V. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet. 2006; 38: 1424-1429.

Gamer LW, Ho V, Cox K, Rosen, V. Expression and function of BMP3 during chick limb development. Dev Dyn 2008; 237: 1691-8

Tsuji K, Cox K, Gamer LW, Gaf D, Economides A, Rosen V. Conditional deletion of BMP7 from the limb does not affect bone formation or fracture repair. J Orthop Res 2010; 28: 384-9.

Gamer LW, Tsuji K, Cox K, Capelo LP, Lowery J, Beppu H, Rosen V. BMPR-II is dispensible for formation of the limb skeleton. Genesis 2011; May 2

Pazin DE, Gamer LW, Cox KA and Rosen V. Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct development of the knee and elbow. Dev Dyn 2012, 241: 1861-26.

Lowery JW, Lavigne AW, Kokabu S and Rosen V. Comparative genomics identified the mouse Bmp3 promoter and an upstream evolutionary conserved region (ECR) in mammals. PLoS One 2013, 8: e57840 Pazin DE, Gamer LW, Capelo LP, Cox KA and Rosen V. Gene signature of the embryonic meniscus. J Orthop Res 2014, 32: 46-53.



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