BBS Faculty Member - Soumya Raychaudhuri

Soumya Raychaudhuri

Division of Genetics and Rheumatology
Department of Medicine, BWH

Harvard Medical School
NRB Building, Room 250, 255
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: 617-525-4484
Fax: 617-525-4488
Email: soumya@broadinstitute.org
Visit my lab page here.



Immune diseases such as lupus or rheumatoid arthritis are not caused by an isolated insult resulting in a single dysfunctional gene or pathway, but rather a systemic dysregulation of multiple genes and pathways. Our group uses methods in computational genomics, bioinformatics, and human genetics to better understand the critical elements of dysregulation within the immune system that results in human diseases. We are specifically interested in gene discovery, fine-mapping disease alleles, and integrative functional genomics of autoimmune diseases.

Our group is interested in (1) using genomics and genetics to identify germline and somatic mutations that predispose to immune-mediated diseases, (2) using those same mutations to identify common pathways, biological processes, and cell-types that play a key role in disease predisposition, and (3) defining the role of those systems within the context of disease pathogenesis. For each of these broad goals, the group heavily emphasizes statistical and computational methods.















Last Update: 8/22/2013



Publications

Stahl EA, Wegmann D, Trynka G, Gutierrez-Achury J, Do R, et al. (2012) Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat Genet 44: 483-489.

Raychaudhuri S, Sandor C, Stahl EA, Freudenberg J, Lee HS, et al. (2012) Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet 44: 291-296.

Raychaudhuri S, Iartchouk O, Chin K, Tan PL, Tai AK, et al. (2011) A rare penetrant mutation in CFH confers high risk of age-related macular degeneration. Nat Genet 43: 1232-1236.

Raychaudhuri S (2011) Mapping rare and common causal alleles for complex human diseases. Cell 147: 57-69.

Hu X, Kim H, Stahl E, Plenge R, Daly M, et al. (2011) Integrating autoimmune risk Loci with gene-expression data identifies specific pathogenic immune cell subsets. Am J Hum Genet 89: 496-506.

Raychaudhuri S, Korn JM, McCarroll S, International Schizophrenia Consortium, Altshuler D, et al. (2010) Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function. PLoS Genet 6: e1001097.

Raychaudhuri S (2006) Computational text analysis for functional genomics and bioinformatics. Oxford: Oxford University Press. 288 p.



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