Department of Obstetrics, Gynecology and Reproductive Biology
Department of Pathology
New Research Building, Rm. 160D
77 Avenue Louis Pasteur
Boston, MA 02115
Lab Members: 1 postdoctoral fellow, 1 graduate student
Several long-term research projects in human genetics are ongoing in my laboratory. An overall theme is to apply evolving techniques in molecular cytogenetics to address problems in human cytogenetics; our interests include
chromosomal rearrangements in constitutional and acquired cytogenetic disorders. A major endeavor is underway to identify genes that predispose women to develop uterine leiomyomata, common benign pelvic tumors that are the most frequent indication for hysterectomy in the United States (http://www.fibroids.net). Another effort is to identify genes involved in human development, known as DGAP (Developmental Genome Anatomy Project, (http://dgap.harvard.edu), and uses naturally occurring human chromosomal rearrangements in association with major congenital anomalies as the biological reagents for gene discovery. A project to decipher genes involved in a variety of human tumors, known as TGAP (Tumor Genome Anatomy Project), is under development, and employs novel chromosomal rearrangements identified in patients evaluated in the clinical cytogenetics laboratory to discover new diagnostic and prognostic markers and to illuminate pathways in tumor biology. Lastly, another primary interest in the laboratory is to identify genes involved in hearing and deafness disorders (http://hearing.bwh.harvard.edu) using expressed sequences from a human fetal cochlear library, a cochlear cDNA microarray, and mouse models of human deafness disorders.
Robertson NG, Jones SM, Sivakumaran TA, Giersch ABS, Jurado SA, Call LM, Miller CE, Maison SF, Liberman MC, Morton CC: A targeted Coch missense mutation: a knock-in mouse model for DFNA9 late-onset hearing loss and vestibular dysfunction. Hum. Mol. Genet. 2008; 17:3426-3434.
Higgins AW, Alkuraya FS, Bosco AF, Brown KK, Bruns GAP, Donovan DJ, Eisenman R, Fan Y, Farra CG, Ferguson HL, Gusella JF, Harris DJ, Herrick SR, Kelly C, Kim H-G, Kishikawa S, Korf BR, Kulkarni S, Lally E, Leach NT, Lemyre E, Lewis J, Ligon AH, Lu W, Maas RL, MacDonald ME, Moore SDP, Peters RE, Quade BJ, Quintero-Rivera F, Saadi I, Shen Y, Shendure J, Williamson RE, Morton CC: Characterization of apparently balanced chromosomal rearrangements from the Developmental Genome Anatomy Project. Am. J. Hum. Genet. 2008; 82:712-722.
Hodge JC, T.Cuenco K, Huyck KL, Somasundaram P, Panhuysen CIM, Stewart EA, Morton CC: Uterine leiomyomata and decreased height: A common HMGA2 predisposition allele. Hum. Genet. 2009; 125:257-263.
Poitras J, Dal Cin P, Aster JC, DeAngelo DJ, Morton CC: Novel SSBP2-JAK2 fusion gene resulting from a t(5;9)(q14.1; p24.1) in pre-B acute lymphocytic leukemia. Genes Chromosomes Cancer 2008;47:884-889.
For a complete listing of publications click here.
Last Update: 7/26/2012