BBS Faculty Member - Thomas Michel

Thomas Michel

Co-Director, Leder Human Biology and Translational Medicine Program

Brigham and Women's Hospital
Thorn Bldg., 12th Floor, Room 1210A
75 Francis St
Boston, MA 02115
Tel: 617-732-7376
Fax: 617-732-5132
Email: thomas_michel@hms.harvard.edu
Lab Members: 6 postdoctoral fellows, 1 graduate student, 2 undergraduate students
Visit my lab page here.

My lab explores signal transduction pathways in the cells and tissues of the cardiovascular system. We have a particular focus on applying biochemical methods and cell imaging approaches using informative biosensors to probe nitric oxide synthase signaling pathways and their interactions with reactive oxygen species in endothelial cells and cardiac myocytes, studying cultured cell systems, animal models of cardiovascular disease states, and human cells and tissues.

Last Update: 6/2/2014

Publications

For a complete listing of publications click here.

Kalwa H, Sartoretto JL, Sartoretto S, and Michel T. Angiotensin-II and MARCKS: a hydrogen peroxide- and Rac1-dependent signaling pathway in vascular endothelium. J Biol Chem 2012, 287: 29147-29158.

Sartoretto J, Kalwa H, Romero N, and Michel T. In vivo imaging of NO and H2O2 in cardiac myocytes. Methods in Enzymology 2013, 528:61-78.

Michel T. R is for Arginine. Circulation 2013, 128:1400-1404.

Shiroto T, Romero N, Sugiyama T, Sartoretto J, Kalwa H, Yan Z, Shimokawa H, Michel T. Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium. PLoS ONE 2014, 9(2): e87871. doi:10.1371/journal.pone.0087871.

Kalwa H, Sartoretto J, Martinelli R, Romero N, Steinhorn B, Tao M, Ozaki K, Carman C, Michel T A central role for hydrogen peroxide in P2Y1 ADP receptor-mediated cellular responses in vascular endothelium. Proc Nat Acad Sci USA 2014, Mar 4;111(9):3383-8. doi: 10.1073/pnas.1320854111.