Thomas Michel, MD, PhD
Co-Director, Leder Human Biology and Translational Medicine Program
Thorn Bldg., 12th Floor, Room 1210A
75 Francis St
Boston, MA 02115
Tel: 617-732-7376
Fax: 617-732-5132
Email: thomas_michel@hms.harvard.edu
Lab Members: 6 postdoctoral fellows, 1 graduate student, 2 undergraduate students
Visit my lab page here.
My lab explores signal transduction pathways in the cells and tissues of the cardiovascular system. We have a particular focus on applying biochemical methods and cell imaging approaches using informative biosensors to probe nitric oxide synthase signaling pathways and their interactions with reactive oxygen species in endothelial cells and cardiac myocytes, studying cultured cell systems, animal models of cardiovascular disease states, and human cells and tissues.
References:
Kalwa H and Michel T. The MARCKS protein plays a critical role in phosphatidylinositol 4,5-bisphosphate metabolism and directed cell movement in vascular endothelial cells. J Biol Chem 2011, 286: 2320-2333.
Sartoretto J, Kalwa H, Pluth M, Lippard S and Michel T. Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis. Proc Natl Acad Sci USA 2011, 108: 15792-15797.
Kou R, Shiroto T, Sartoretto JL and Michel T. Suppression of Gas synthesis by simvastatin in vascular endothelial cells. J Biol Chem 2012, 287:2643-51.
Kalwa H, Sartoretto JL, Sartoretto SM, and Michel T. Angiotensin-II and MARCKS: a hydrogen peroxide– and Rac1–dependent signaling pathway in vascular endothelium. J Biol Chem 2012, published online 10.1074/jbc.M112.381517.
For a complete listing of publications click here.
Last Update: 7/26/2012