BBS Faculty Member - Hongbo Luo

Hongbo Luo

Department of Pathology

Boston Children's Hospital
811 Enders Building
320 Longwood Ave.
Boston, MA 02115
Tel: 617-910-2303
Fax: 617-730-0885
Email: hongbo.luo@childrens.harvard.edu
Lab Members: 4 postdoctoral fellows, 2 students
Visit my lab page here.



Signal transduction in innate immunity

One of the major players in innate immune system is neutrophil which is the most abundant cell type among circulating white blood cells and constitutes the first line of host defense against invading bacteria and other pathogens. The long-term goal of our research is to elucidate the molecular mechanisms that control the number and function of neutrophil at the site of inflammation. We are also interested in the potential role of neutrophil in regulating bone marrow hematopoiesis and tumorigenesis. Our research focuses on

1) signal pathways mediating neutrophil directional movement (chemotaxis).
2) molecular mechanism of neutrophil spontaneous cell death.
3) cell signaling in macrophage-mediated neutrophil clearance.
4) the potential role of neutrophils and acute inflammation in regulating bone marrow hematopoiesis
5) the role of neutrophils in tumor immunology

Currently, we are particularly interested in signaling pathways mediated by inositol phospholipid PtdIns(3,4,5)P3, inositol phosphates (e.g. InsP4 and InsP7), and reactive oxygen species (ROS). We utilize a wide variety of approaches ranging from basic molecular and cell biology methods to high throughput chemical genetic screening and animal inflammation models to dissect these pathways.

For other available projects, please check our website.



Last Update: 8/22/2013



Publications

For a complete listing of publications click here.

 


 

Jo, H., S. Mondal, D. Tan, E. Nagata, A.K. Sharma, Q. Hou, K. Shanmugasundaram, J. Tang, H. Man, A.C. Rigby, and H.R. Luo, Small molecule-induced cytosolic activation of Akt rescues ischemia-elicited neuronal death. Proc Natl Acad Sci U S A, 2012. In press.

Prasad, A., Y. Jia, A. Chakraborty, Y. Li, S.K. Jain, J. Zhong, S.G. Roy, F. Loison, S. Mondal, J. Sakai, C. Blanchard, S.H. Snyder, and H.R. Luo, Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling.
Nat Immunol, 2011. 12(8): p. 752-60.

Jia, Y, Subramanian, KK, Erneux, C, Pouillon, V, Hattori, H, Jo, H, You, J, Zhu, D, Schurmans, S, and Luo, HR. Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils.
Immunity, 2007; 27: 453-467.



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