BBS Faculty Member - Isaac Kohane

Isaac Kohane

Director, HST's Bioinformatics and Integrative Genomics Program
Co-Director, HMS Center for Biomedical Informatics

Harvard Medical School
Countway Library of Medicine, Room 435
10 Shattuck St.
Boston, MA 02115
Tel: 617-432-2144
Fax: 617-432-0693
Visit my lab page here.

Why is it easier to find out what experience shoppers worldwide have had with the latest digital camera than it is to determine what adverse events patients have had with a particular drug? Why are blood tests and X-rays repeated needlessly? Why can one replace an application on an iPhone with a mouse click and require a team of engineers to do it for an electronic health record system? Mirroring the systems approach taken in biology,we have attempted to answer (through design and implementation) these questions including the pioneering of personal health record systems, distributed clinical query systems, and privacy protection mechanisms and policies. Most recently, we have focused on how to re-engineer electronic health record systems so that they are as easy to manage and customize as other complex but consumer facing systems (e.g. the iPhone) which fundamentally support our notion of substitutability.

Last Update: 8/22/2013


For a complete listing of publications click here.



Kohane IS, Taylor PL. Multidimensional results reporting to participants in genomic studies: getting it right. Sci Transl Med. 2010 Jun 23;2(37):37cm19.

Brownstein JS, Murphy SN, Goldfine AB, Grant RW, Sordo M, Gainer V, Colecchi JA, Dubey A, Nathan DM, Glaser JP, Kohane IS. Rapid identification of myocardial infarction risk associated with diabetic medications using electronic medical records. Diabetes Care. 2009 Dec 15.

Murphy S, Churchill S, Bry L, Chueh H, Cai T, Weiss S, Lazarus R, Zeng Q, Dubey A, Gainer V, Mendis M, Glaser J, Kohane I. Instrumenting the health care enterprise for discovery research in the genomic era. Genome Res. 2009 Jul 14.

Weber GM, Murphy SN, McMurry AJ, Macfadden D, Nigrin DJ, Churchill S, Kohane IS. The Shared Health Research Information Network (SHRINE): A prototype federated query tool for clinical data repositories. J Am Med Inform Assoc. 2009 Jun 30.

Mandl KD, Kohane IS. No small change for the health information economy. N Engl J Med. 2009 Mar 26;360(13):1278-81.

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