Department of Medicine
NRB Building, Room 458
77 Ave Louis Pasteur
Boston, MA 02115
Visit my lab page here.
Our laboratory seeks to understand the signals that indicate organ injury and regulate growth and regeneration. The inability to recover from acute injury can lead to organ failure, while a dysregulated regenerative response in the setting of chronic injury may contribute to cancer formation. Our specific interest is to define the similarities between development and regeneration of the liver, an important organ for the organism’s metabolism and protein synthesis with remarkable regenerative capacities. We investigate zebrafish as the primary model to discover novel regulatory pathways of liver development and evaluate their importance for recovery after toxic and physical injury.Using chemical and genetic modulation, we assess organ formation, repair and carcinogenesis by in vivo imaging, functional genomic methods, and histological analysis to define the principal molecular and cellular mechanisms essential for organ growth.
Goessling W, North TE, Ceol C, Lee S, Lord A, Weidinger G, Bourque C, Haramis AP, Puder M, Clevers H, Moon RT, Zon LI. APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Developmental Biology 320:161-174, 2008.
Goessling W*, North TE*, Schmitt S, Lord AM, Lee S, Stoick-Cooper CL, Weidinger G, Puder M, Daley GQ, Moon RT, Zon LI. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell 136(6):1136-47, 2009.
North TE*, Goessling W*, Peeters M, Li P, Ceol C, Lord AM, Weber GJ, Harris J, Cutting CC, Huang P, Dzierzak E, Zon LI. Hematopoietic stem cell development is dependent on blood flow. Cell 137(4):736-48, 2009.
North TE, Babu IR, Vedder LM, Lord AM, Wishnok JS, Tannenbaum SR, Zon LI, Goessling W. PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17315-20.
Goessling W, Allen RS, Guan X, Jin P, Uchida N, Dovey M, Harris JM, Metzger ME, Bonifacino AC, Stroncek D, Stegner J, Armant M, Schlaeger T, Tisdale JF, Zon LI, Donahue RE, North TE. Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell Stem Cell. 2011 Apr 8;8(4):445-58.
For a complete listing of publications click here.
Last Update: 3/4/2013