BBS Faculty Member - Jenna Galloway

Jenna Galloway

Department of Orthopaedics

Massachusetts General Hospital
185 Cambridge Street, CPZN 4254
Boston, MA 02114
Tel: 617-643-4958
Fax: 617-724-2662
Email: jgalloway1@partners.org
Visit my lab page here.



Research in our laboratory is committed to expanding our molecular understanding of the formation and regeneration of tendons and ligaments. Injuries to tendons and ligaments result in a slow and imperfect regenerative response. In most cases, the original biomechanical properties of the tissue are never restored, resulting in scarring and limited mobility. We use a multidisciplinary approach, combining genetic and chemical screening with different model systems such as zebrafish and stem cells, to identify essential regulators of tendon and ligament biology.

One major area of research in the laboratory aims to identify the cues that direct progenitor cells to become mature tendons and ligaments. During embryogenesis, progenitor cell populations will form the tendon or cartilage tissues in our limbs, head and spine. We are interested in elucidating the pathways that regulate this fate decision, expand tendon and ligament populations, and promote more faithful differentiation into these lineages.

We are also focused on understanding the critical factors that coordinate the attachments between muscle, tendon, and bone. By combining live-imaging and high-throughput screening approaches, our goal is to identify the molecules and cellular behaviors governing these processes. In the long term, my laboratory aims to transform these discoveries into regenerative biology solutions to better heal and repair tendon and ligament injuries.



Last Update: 9/4/2014



Publications

Galloway, J.L., Wingert, R.A., Thisse, C., Thisse, B., and Zon, L.I. (2005). Loss of Gata1 but not Gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Dev. Cell, 8(1), 109-116.

Galloway JL and Tabin CJ. (2008) Classic limb patterning models and the work of Dennis Summerbell. Development, 135(16):2683-7.

Burns CE*,
Galloway JL*, Smith AC, Keefe MD, Cashman TJ, Paik EJ, Mayhall EA, Amsterdam AH, Zon LI. (2009) A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood, 113(23):5776-82. *co-first authorship

Galloway JL*, Delgado I*, Ros MA, and Tabin CJ. (2009) A reevaluation of X-irradiation-induced phocomelia and proximodistal limb patterning. Nature, 460(7253):400-4. *co-first authorship



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